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@ARTICLE{Baldermann:1037231,
      author       = {Baldermann, Juan Carlos and Petry-Schmelzer, Jan Niklas and
                      Schüller, Thomas and Mahfoud, Lin and Brandt, Gregor A. and
                      Dembek, Till A. and van der Linden, Christina and Krauss,
                      Joachim K. and Szejko, Natalia and Müller-Vahl, Kirsten R.
                      and Ganos, Christos and Al-Fatly, Bassam and Heiden, Petra
                      and Servello, Domenico and Galbiati, Tommaso and Johnson,
                      Kara A. and Butson, Christopher R. and Okun, Michael S. and
                      Andrade, Pablo and Domschke, Katharina and Fink, Gereon
                      Rudolf and Fox, Michael D. and Horn, Andreas and Kuhn, Jens
                      and Visser-Vandewalle, Veerle and Barbe, Michael T.},
      title        = {{A} critical role of action-related functional networks in
                      {G}illes de la {T}ourette syndrome},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-00564},
      pages        = {10687},
      year         = {2024},
      note         = {Open Access funding enabled and organized by Projekt
                      DEAL.This study was funded by the German Research Foundation
                      (CRC-1451,Project 431549029-C07, to J.C.B. and V.V.V.) and
                      the Else Kröner-Fresenius-Stiftung (grant number
                      $2022_EKES.23$ to J.C.B.). A.H. wassupported by the German
                      Research Foundation (Deutsche Forschungsgemeinschaft,
                      424778381 – TRR 295), Deutsches Zentrum für Luft-
                      undRaumfahrt (DynaSti grant within the EU Joint Programme
                      NeurodegenerativeDisease Research, JPND), the National
                      Institutes of Health (R0113478451, 1R01NS127892-01, 2R01
                      MH113929 $\&$ UM1NS132358), and theNew Venture Fund (FFOR
                      Seed Grant). JNPS was funded by the CologneClinician
                      Scientist Program (CCSP) / Faculty of Medicine / University
                      ofCologne, funded by theGerman Research Foundation (DFG, FI
                      773/15-1).},
      abstract     = {Gilles de la Tourette Syndrome (GTS) is a chronic tic
                      disorder, characterized by unwanted motor actions and
                      vocalizations. While brain stimulation techniques show
                      promise in reducing tic severity, optimal target networks
                      are not well-defined. Here, we leverage datasets from two
                      independent deep brain stimulation (DBS) cohorts and a
                      cohort of tic-inducing lesions to infer critical networks
                      for treatment and occurrence of tics by mapping stimulation
                      sites and lesions to a functional connectome derived from
                      1,000 healthy participants. We find that greater tic
                      reduction is linked to higher connectivity of DBS sites (N =
                      37) with action-related functional resting-state networks,
                      i.e., the cingulo-opercular (r = 0.62; p < 0.001) and
                      somato-cognitive action networks (r = 0.47; p = 0.002).
                      Regions of the cingulo-opercular network best match the
                      optimal connectivity profiles of thalamic DBS. We replicate
                      the significance of targeting cingulo-opercular and
                      somato-cognitive action network connectivity in an
                      independent DBS cohort (N = 10). Finally, we demonstrate
                      that tic-inducing brain lesions (N = 22) exhibit similar
                      connectivity to these networks. Collectively, these results
                      suggest a critical role for these action-related networks in
                      the pathophysiology and treatment of GTS.},
      cin          = {INM-3},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / SFB 1451 C07 - Neuronale Grundlagen der Bildung
                      und Unterdrückung motorischer Tics (C07) (458687122)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)458687122},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39681552},
      UT           = {WOS:001379684000003},
      doi          = {10.1038/s41467-024-55242-6},
      url          = {https://juser.fz-juelich.de/record/1037231},
}