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| 001 | 1037231 | ||
| 005 | 20250203124515.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-024-55242-6 |2 doi |
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| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Baldermann, Juan Carlos |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a A critical role of action-related functional networks in Gilles de la Tourette syndrome |
| 260 | _ | _ | |a [London] |c 2024 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1736868073_9881 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 500 | _ | _ | |a Open Access funding enabled and organized by Projekt DEAL.This study was funded by the German Research Foundation (CRC-1451,Project 431549029-C07, to J.C.B. and V.V.V.) and the Else Kröner-Fresenius-Stiftung (grant number 2022_EKES.23 to J.C.B.). A.H. wassupported by the German Research Foundation (Deutsche Forschungsgemeinschaft, 424778381 – TRR 295), Deutsches Zentrum für Luft- undRaumfahrt (DynaSti grant within the EU Joint Programme NeurodegenerativeDisease Research, JPND), the National Institutes of Health (R0113478451, 1R01NS127892-01, 2R01 MH113929 & UM1NS132358), and theNew Venture Fund (FFOR Seed Grant). JNPS was funded by the CologneClinician Scientist Program (CCSP) / Faculty of Medicine / University ofCologne, funded by theGerman Research Foundation (DFG, FI 773/15-1). |
| 520 | _ | _ | |a Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS. |
| 536 | _ | _ | |a 5251 - Multilevel Brain Organization and Variability (POF4-525) |0 G:(DE-HGF)POF4-5251 |c POF4-525 |f POF IV |x 0 |
| 536 | _ | _ | |a SFB 1451 C07 - Neuronale Grundlagen der Bildung und Unterdrückung motorischer Tics (C07) (458687122) |0 G:(GEPRIS)458687122 |c 458687122 |x 1 |
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| 700 | 1 | _ | |a Petry-Schmelzer, Jan Niklas |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Schüller, Thomas |0 0000-0003-1232-7871 |b 2 |
| 700 | 1 | _ | |a Mahfoud, Lin |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Brandt, Gregor A. |0 0000-0002-9984-2069 |b 4 |
| 700 | 1 | _ | |a Dembek, Till A. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a van der Linden, Christina |0 0000-0003-2091-4638 |b 6 |
| 700 | 1 | _ | |a Krauss, Joachim K. |0 0000-0002-0675-9064 |b 7 |
| 700 | 1 | _ | |a Szejko, Natalia |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Müller-Vahl, Kirsten R. |0 0000-0002-7181-7419 |b 9 |
| 700 | 1 | _ | |a Ganos, Christos |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Al-Fatly, Bassam |0 0000-0003-0067-6177 |b 11 |
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| 700 | 1 | _ | |a Andrade, Pablo |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Domschke, Katharina |0 0000-0002-2550-9132 |b 19 |
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| 700 | 1 | _ | |a Fox, Michael D. |0 0000-0001-8848-6399 |b 21 |
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| 700 | 1 | _ | |a Visser-Vandewalle, Veerle |0 0000-0002-5274-7929 |b 24 |
| 700 | 1 | _ | |a Barbe, Michael T. |0 P:(DE-Juel1)131613 |b 25 |
| 773 | _ | _ | |a 10.1038/s41467-024-55242-6 |g Vol. 15, no. 1, p. 10687 |0 PERI:(DE-600)2553671-0 |n 1 |p 10687 |t Nature Communications |v 15 |y 2024 |x 2041-1723 |
| 856 | 4 | _ | |u Nat Commun . 2024 Dec 16;15(1):10687. |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1037231/files/PDF.pdf |y OpenAccess |
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