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@ARTICLE{Brandt:1037243,
      author       = {Brandt, Gregor A. and Stopic, Vasilija and van der Linden,
                      Christina and Strelow, Joshua N. and Petry-Schmelzer, Jan N.
                      and Baldermann, Juan Carlos and Visser-Vandewalle, Veerle
                      and Fink, Gereon R. and Barbe, Michael T. and Dembek, Till
                      A.},
      title        = {{A} {R}etrospective {C}omparison of {M}ultiple {A}pproaches
                      to {A}natomically {I}nformed {C}ontact {S}election in
                      {S}ubthalamic {D}eep {B}rain {S}timulation for
                      {P}arkinson’s {D}isease},
      journal      = {Journal of Parkinson's Disease},
      volume       = {14},
      number       = {3},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2025-00576},
      pages        = {575 - 587},
      year         = {2024},
      note         = {We acknowledge support for the article processing charge
                      from the DFG (German Research Foundation 491454339).},
      abstract     = {Background: Conventional deep brain stimulation (DBS)
                      programming via trial-and-error warrants improvement to
                      ensure swift achievement of optimal outcomes. The definition
                      of a sweet spot for subthalamic DBS in Parkinson's disease
                      (PD-STN-DBS) may offer such advancement.Objective: This
                      investigation examines the association of long-term motor
                      outcomes with contact selection during monopolar review and
                      different strategies for anatomically informed contact
                      selection in a retrospective real-life cohort of
                      PD-STN-DBS.Methods: We compared contact selection based on a
                      monopolar review (MPR) to multiple anatomically informed
                      contact selection strategies in a cohort of 28 PD patients
                      with STN-DBS. We employed a commercial software package for
                      contact selection based on visual assessment of individual
                      anatomy following two predefined strategies and two
                      algorithmic approaches with automatic targeting of either
                      the sensorimotor STN or our previously published sweet spot.
                      Similarity indices between chronic stimulation and contact
                      selection strategies were correlated to motor outcomes at 12
                      months follow-up.Results: Lateralized motor outcomes of
                      chronic DBS were correlated to the similarity between
                      chronic stimulation and visual contact selection targeting
                      the dorsal part of the posterior STN (rho = 0.36, p =
                      0.007). Similar relationships could not be established for
                      MPR or any of the other investigated strategies.Conclusions:
                      Our data demonstrates that a visual contact selection
                      following a predefined strategy can be linked to beneficial
                      long-term motor outcomes in PD-STN-DBS. Since similar
                      correlations could not be observed for the other approaches
                      to anatomically informed contact selection, we conclude that
                      clear definitions and prospective validation of any approach
                      to imaging-based DBS-programming is warranted.Keywords:
                      Parkinson’s disease; anatomically informed contact
                      selection; clinical care; deep brain stimulation; imaging
                      guided DBS programming; neuroimaging; retrospective
                      analysis; subthalamic nucleus.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38427498},
      UT           = {WOS:001209040300017},
      doi          = {10.3233/JPD-230200},
      url          = {https://juser.fz-juelich.de/record/1037243},
}