001037247 001__ 1037247 001037247 005__ 20250813203212.0 001037247 0247_ $$2doi$$a10.1093/neuonc/noae082 001037247 0247_ $$2ISSN$$a1522-8517 001037247 0247_ $$2ISSN$$a1523-5866 001037247 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-00580 001037247 0247_ $$2pmid$$a38695575 001037247 0247_ $$2WOS$$aWOS:001269694700001 001037247 037__ $$aFZJ-2025-00580 001037247 082__ $$a610 001037247 1001_ $$0P:(DE-HGF)0$$aWang, Justin Z$$b0 001037247 245__ $$aMeningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients 001037247 260__ $$aOxford$$bOxford Univ. Press$$c2024 001037247 3367_ $$2DRIVER$$aarticle 001037247 3367_ $$2DataCite$$aOutput Types/Journal article 001037247 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1754987750_30977 001037247 3367_ $$2BibTeX$$aARTICLE 001037247 3367_ $$2ORCID$$aJOURNAL_ARTICLE 001037247 3367_ $$00$$2EndNote$$aJournal Article 001037247 520__ $$aMeningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbidity and even mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication. However, unlike other central nervous system (CNS) tumors, a unified molecular taxonomy for meningiomas has not yet been established and remains an overarching goal of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official World Health Organization (cIMPACT-NOW) working group. Additionally, clinical equipoise still remains on how specific meningioma cases and patient populations should be optimally managed. To address these existing gaps, members of the International Consortium on Meningiomas including field-leading experts, have prepared this comprehensive consensus narrative review directed toward clinicians, researchers, and patients. Included in this manuscript are detailed overviews of proposed molecular classifications, novel biomarkers, contemporary treatment strategies, trials on systemic therapies, health-related quality-of-life studies, and management strategies for unique meningioma patient populations. In each section, we discuss the current state of knowledge as well as ongoing clinical and research challenges to road map future directions for further investigation.Keywords: extra-axial; meningioma; methylation; molecular; neurofibromatosis 2; nonmalignant; radiotherapy. 001037247 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0 001037247 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de 001037247 7001_ $$0P:(DE-HGF)0$$aLandry, Alexander P$$b1 001037247 7001_ $$0P:(DE-HGF)0$$aRaleigh, David R$$b2 001037247 7001_ $$00000-0001-5441-1962$$aSahm, Felix$$b3 001037247 7001_ $$00000-0002-5879-9981$$aWalsh, Kyle M$$b4 001037247 7001_ $$0P:(DE-HGF)0$$aGoldbrunner, Roland$$b5 001037247 7001_ $$0P:(DE-HGF)0$$aYefet, Leeor S$$b6 001037247 7001_ $$0P:(DE-HGF)0$$aTonn, Jörg C$$b7 001037247 7001_ $$0P:(DE-HGF)0$$aGui, Chloe$$b8 001037247 7001_ $$0P:(DE-HGF)0$$aOstrom, Quinn T$$b9 001037247 7001_ $$0P:(DE-HGF)0$$aBarnholtz-Sloan, Jill$$b10 001037247 7001_ $$0P:(DE-HGF)0$$aPerry, Arie$$b11 001037247 7001_ $$0P:(DE-HGF)0$$aEllenbogen, Yosef$$b12 001037247 7001_ $$0P:(DE-HGF)0$$aHanemann, C Oliver$$b13 001037247 7001_ $$0P:(DE-HGF)0$$aJungwirth, Gerhard$$b14 001037247 7001_ $$0P:(DE-HGF)0$$aJenkinson, Michael D$$b15 001037247 7001_ $$0P:(DE-HGF)0$$aTabatabai, Ghazaleh$$b16 001037247 7001_ $$0P:(DE-HGF)0$$aMathiesen, Tiit I$$b17 001037247 7001_ $$0P:(DE-HGF)0$$aMcDermott, Michael W$$b18 001037247 7001_ $$0P:(DE-HGF)0$$aTatagiba, Marcos$$b19 001037247 7001_ $$0P:(DE-HGF)0$$ala Fougère, Christian$$b20 001037247 7001_ $$0P:(DE-HGF)0$$aMaas, Sybren L N$$b21 001037247 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b22 001037247 7001_ $$0P:(DE-HGF)0$$aAlbert, Nathalie L$$b23 001037247 7001_ $$0P:(DE-HGF)0$$aBrastianos, Priscilla K$$b24 001037247 7001_ $$0P:(DE-HGF)0$$aEhret, Felix$$b25 001037247 7001_ $$0P:(DE-HGF)0$$aMinniti, Giuseppe$$b26 001037247 7001_ $$0P:(DE-HGF)0$$aLamszus, Katrin$$b27 001037247 7001_ $$0P:(DE-HGF)0$$aRicklefs, Franz L$$b28 001037247 7001_ $$00000-0002-9168-6209$$aSchittenhelm, Jens$$b29 001037247 7001_ $$0P:(DE-HGF)0$$aDrummond, Katharine J$$b30 001037247 7001_ $$0P:(DE-HGF)0$$aDunn, Ian F$$b31 001037247 7001_ $$0P:(DE-HGF)0$$aPathmanaban, Omar N$$b32 001037247 7001_ $$0P:(DE-HGF)0$$aCohen-Gadol, Aaron A$$b33 001037247 7001_ $$0P:(DE-HGF)0$$aSulman, Erik P$$b34 001037247 7001_ $$0P:(DE-HGF)0$$aTabouret, Emeline$$b35 001037247 7001_ $$0P:(DE-HGF)0$$aLe Rhun, Emelie$$b36 001037247 7001_ $$0P:(DE-HGF)0$$aMawrin, Christian$$b37 001037247 7001_ $$0P:(DE-HGF)0$$aMoliterno, Jennifer$$b38 001037247 7001_ $$00000-0002-1748-174X$$aWeller, Michael$$b39 001037247 7001_ $$0P:(DE-HGF)0$$aBi, Wenya$$b40 001037247 7001_ $$0P:(DE-HGF)0$$aGao, Andrew$$b41 001037247 7001_ $$0P:(DE-HGF)0$$aYip, Stephen$$b42 001037247 7001_ $$0P:(DE-HGF)0$$aNiyazi, Maximilian$$b43 001037247 7001_ $$00000-0001-5119-7550$$aAldape, Kenneth$$b44 001037247 7001_ $$0P:(DE-HGF)0$$aWen, Patrick Y$$b45 001037247 7001_ $$0P:(DE-HGF)0$$aShort, Susan$$b46 001037247 7001_ $$00000-0003-3541-2315$$aPreusser, Matthias$$b47 001037247 7001_ $$0P:(DE-HGF)0$$aNassiri, Farshad$$b48 001037247 7001_ $$00000-0002-6637-4502$$aZadeh, Gelareh$$b49$$eCorresponding author 001037247 773__ $$0PERI:(DE-600)2094060-9$$a10.1093/neuonc/noae082$$gVol. 26, no. 10, p. 1742 - 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