| 001 | 1037611 | ||
| 005 | 20251013202054.0 | ||
| 024 | 7 | _ | |a 10.1093/neuonc/noae205 |2 doi |
| 024 | 7 | _ | |a 1522-8517 |2 ISSN |
| 024 | 7 | _ | |a 1523-5866 |2 ISSN |
| 024 | 7 | _ | |a 10.34734/FZJ-2025-00782 |2 datacite_doi |
| 037 | _ | _ | |a FZJ-2025-00782 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zeyen, Thomas |0 0009-0006-2919-8622 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Quantitative assessment of residual tumor is a strong and independent predictor of survival in methylated glioblastoma following radiochemotherapy with lomustine/temozolomide |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1760337229_32277 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a The CeTeG/NOA-09 trial was funded by the German Ministry for Education and Research. |
| 520 | _ | _ | |a ackground: Maximum tumor resection improves overall survival (OS) in patients with glioblastoma. The extent of resection (EOR) is historically dichotomized. The RANO resect group recently proposed criteria for volumetry-based EOR assessment in patients that were treated according to Stupp´s protocol. The purpose of this study was (1) to investigate the prognostic value of EOR in patients receiving combined chemotherapy with lomustine (CCNU)/temozolomide (TMZ), and (2) to analyse the prognostic performance of binary EOR assessment compared to volumetric assessment.Methods: 78 patients with newly diagnosed MGMT-methylated GBM undergoing tumor resection followed by radiochemotherapy with CCNU/TMZ were included in this study. Residual contrast-enhancing (CE) tumor volume after the first resection was measured and its influence on OS and PFS was analysed using uni- and multivariable Cox regression analysis as well as two-sided log rank test. Patients were divided into RTV ≤1 cm³, >1 cm³ - ≤5 cm³ and >5 cm³ following the proposed criteria of the RANO resect group.Results: Prolonged OS was associated with age <60 years, low RTV, and gross total resection (GTR). Residual tumor volume (RTV) had a superior prognostic value compared to binary EOR assessment. Patients with total or near total resection of CE tumor (≤1 cm³ RTV) showed prolonged OS (median 54.4 months, 95% CI 46.94-not reached), with a 5-year survival rate of 49%.Conclusion: Low RTV is associated with increased survival in glioblastoma patients undergoing radiochemotherapy with CCNU/TMZ. This study demonstrates the applicability of the recently proposed RANO resect criteria in this subgroup of patients.Keywords: MGMT-promotor; extend of resection; glioblastoma; residual tumor volume. |
| 536 | _ | _ | |a 5252 - Brain Dysfunction and Plasticity (POF4-525) |0 G:(DE-HGF)POF4-5252 |c POF4-525 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Böhm, Laura |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Paech, Daniel |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Schäfer, Niklas |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Tzaridis, Theophilos |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Duffy, Cathrina |b 5 |
| 700 | 1 | _ | |a Nitsch, Louisa |b 6 |
| 700 | 1 | _ | |a Schneider, Matthias |0 0000-0002-6025-7479 |b 7 |
| 700 | 1 | _ | |a Potthoff, Anna-Laura |b 8 |
| 700 | 1 | _ | |a Schneider-Rothhaar, Javen Lennard |b 9 |
| 700 | 1 | _ | |a Steinbach, Joachim Peter |b 10 |
| 700 | 1 | _ | |a Hau, Peter |b 11 |
| 700 | 1 | _ | |a Kowalski, Thomas |b 12 |
| 700 | 1 | _ | |a Seidel, Clemens |b 13 |
| 700 | 1 | _ | |a Krex, Dietmar |b 14 |
| 700 | 1 | _ | |a Grauer, Oliver |b 15 |
| 700 | 1 | _ | |a Goldbrunner, Roland |b 16 |
| 700 | 1 | _ | |a Zeiner, Pia Susan |b 17 |
| 700 | 1 | _ | |a Tabatabai, Ghazaleh |0 0000-0002-3542-8782 |b 18 |
| 700 | 1 | _ | |a Galldiks, Norbert |0 P:(DE-Juel1)143792 |b 19 |
| 700 | 1 | _ | |a Stummer, Walter |0 0000-0002-3460-0640 |b 20 |
| 700 | 1 | _ | |a Hattingen, Elke |b 21 |
| 700 | 1 | _ | |a Glas, Martin |0 0000-0003-3167-3403 |b 22 |
| 700 | 1 | _ | |a Gkika, Eleni |b 23 |
| 700 | 1 | _ | |a Vatter, Hartmut |b 24 |
| 700 | 1 | _ | |a Radbruch, Alexander |b 25 |
| 700 | 1 | _ | |a Herrlinger, Ulrich |b 26 |
| 700 | 1 | _ | |a Weller, Johannes |b 27 |
| 700 | 1 | _ | |a Schaub, Christina |b 28 |
| 773 | _ | _ | |a 10.1093/neuonc/noae205 |g p. noae205 |0 PERI:(DE-600)2094060-9 |n 2 |p 557-566 |t Neuro-Oncology |v 27 |y 2025 |x 1522-8517 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1037611/files/PDF-8.pdf |
| 856 | 4 | _ | |y Published on 2024-10-01. Available in OpenAccess from 2025-10-01. |u https://juser.fz-juelich.de/record/1037611/files/post-print.pdf |
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