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@ARTICLE{Galldiks:1037621,
author = {Galldiks, Norbert and Lohmann, Philipp and Friedrich,
Michel and Werner, Jan-Michael and Stetter, Isabelle and
Wollring, Michael M and Ceccon, Garry and Stegmayr, Carina
and Krause, Sandra and Fink, Gereon R and Law, Ian and
Langen, Karl-Josef and Tonn, Joerg-Christian},
title = {{PET} imaging of gliomas: {S}tatus quo and quo vadis?},
journal = {Neuro-Oncology},
volume = {26},
number = {$Supplement_9$},
issn = {1522-8517},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2025-00792},
pages = {S185 - S198},
year = {2024},
abstract = {PET imaging, particularly using amino acid tracers, has
become a valuable adjunct to anatomical MRI in the clinical
management of patients with glioma. Collaborative
international efforts have led to the development of
clinical and technical guidelines for PET imaging in
gliomas. The increasing readiness of statutory health
insurance agencies, especially in European countries, to
reimburse amino acid PET underscores its growing importance
in clinical practice. Integrating artificial intelligence
and radiomics in PET imaging of patients with glioma may
significantly improve tumor detection, segmentation, and
response assessment. Efforts are ongoing to facilitate the
clinical translation of these techniques. Considerable
progress in computer technology developments (eg quantum
computers) may be helpful to accelerate these efforts.
Next-generation PET scanners, such as long-axial
field-of-view PET/CT scanners, have improved image quality
and body coverage and therefore expanded the spectrum of
indications for PET imaging in Neuro-Oncology (eg PET
imaging of the whole spine). Encouraging results of clinical
trials in patients with glioma have prompted the development
of PET tracers directing therapeutically relevant targets
(eg the mutant isocitrate dehydrogenase) for novel
anticancer agents in gliomas to improve response assessment.
In addition, the success of theranostics for the treatment
of extracranial neoplasms such as neuroendocrine tumors and
prostate cancer has currently prompted efforts to translate
this approach to patients with glioma. These advancements
highlight the evolving role of PET imaging in
Neuro-Oncology, offering insights into tumor biology and
treatment response, thereby informing personalized patient
care. Nevertheless, these innovations warrant further
validation in the near future.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
pid = {G:(DE-HGF)POF4-5252},
typ = {PUB:(DE-HGF)16},
pubmed = {38970818},
UT = {WOS:001263250000001},
doi = {10.1093/neuonc/noae078},
url = {https://juser.fz-juelich.de/record/1037621},
}