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001037823 1001_ $$0P:(DE-HGF)0$$aAurino, Elena$$b0$$eFirst author
001037823 245__ $$aFunctional and Bioactive Benefits of Selected Microalgal Hydrolysates Assessed In Silico and In Vitro
001037823 260__ $$aBasel$$bMDPI$$c2025
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001037823 500__ $$aDear library team, the grant under which that publication was done is theNORTH-WEST EUROPE INTERREG, grant number NWE 639 as part of the IDEA+ project
001037823 520__ $$aBIOPEP-UWM, a peptide database, contains 5128 peptides from a myriad of resources. Five listed peptides are Angiotensin-I-converting enzyme (ACE-1; EC3.4.15.1) inhibitory peptides derived from a red alga, while two from Chlorella vulgaris have anti-cancer and antioxidative bioactivities. Herein, we describe a process combining hydrolysis with two enzymes, Alcalase and Viscozyme, and filtration to generate protein-rich, bioactive peptide-containing hydrolysates from mixed species of Chlorella sp. and Scenedesmus sp. The potential of generated algal hydrolysates to act as food ingredients was determined by assessment of their techno-functional (foaming, emulsification, solubility, water holding, and oil holding capacity) properties. Bioactive screening of hydrolysates in vitro combined with mass spectrometry (MS) and in silico predictions identified bioactive and functional hydrolysates and six novel peptides. Peptides derived from Chlorella mix have the sequences YDYIGNNPAKGGLF and YIGNNPAKGGLF with predicted anti-inflammatory (medium confidence) and umami potential. Peptides from Scenedesmus mix have sequences IEWYGPDRPKFL, RSPTGEIIFGGETM, TVQIPGGERVPFLF, and IEWYGPDRPKFLGPF with predicted anti-inflammatory, anti-diabetic, and umami attributes. Such microalgal hydrolysates could provide essential amino acids to consumers as well as tertiary health benefits to improve human global health.
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001037823 7001_ $$0P:(DE-HGF)0$$aMora, Leticia$$b1
001037823 7001_ $$0P:(DE-HGF)0$$aMarzocchella, Antonio$$b2
001037823 7001_ $$0ORCID$$aKuchendorf , Christina M.$$b3
001037823 7001_ $$0P:(DE-HGF)0$$aAckermann, Bärbel$$b4
001037823 7001_ $$0P:(DE-HGF)0$$aHayes, Maria$$b5$$eCorresponding author
001037823 770__ $$aMarine Algal Biotechnology and Applications
001037823 773__ $$0PERI:(DE-600)2175190-0$$a10.3390/md23020053$$n2$$p53$$tMarine drugs$$v23$$x1660-3397$$y2025
001037823 8564_ $$uhttps://www.mdpi.com/1660-3397/23/2/53#
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001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Food BioSciences, Teagasc Food Research Centre$$b0
001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Dipartimento di Ingegneria Chimica, dei Materiali, e della Produzione Industriale, Università degli Studi di Napoli ‘Federico II’$$b0
001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$aInstituto de Agroquímica y Tecnología de Alimentos (CSIC),$$b1
001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Dipartimento di Ingegneria Chimica, dei Materiali, e della Produzione Industriale, Università degli Studi di Napoli ‘Federico II’$$b2
001037823 9101_ $$0I:(DE-588b)5008462-8$$6ORCID$$aForschungszentrum Jülich$$b3$$kFZJ
001037823 9101_ $$0I:(DE-HGF)0$$6ORCID$$a Institute of Bio- and Geosciences, IBG-2—Plant Sciences Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str., 52428 Jülich, Germany$$b3
001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Stadt Erftstadt, Stabsstelle Klimaschutz, Holzdamm 10, 50374 Erftstadt, Germany$$b4
001037823 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Food BioSciences, Teagasc Food Research Centre, Ashtown, D15 DY05 Dublin, Ireland$$b5
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