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@ARTICLE{Aurino:1037823,
      author       = {Aurino, Elena and Mora, Leticia and Marzocchella, Antonio
                      and Kuchendorf , Christina M. and Ackermann, Bärbel and
                      Hayes, Maria},
      title        = {{F}unctional and {B}ioactive {B}enefits of {S}elected
                      {M}icroalgal {H}ydrolysates {A}ssessed {I}n {S}ilico and
                      {I}n {V}itro},
      journal      = {Marine drugs},
      volume       = {23},
      number       = {2},
      issn         = {1660-3397},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2025-00975},
      pages        = {53},
      year         = {2025},
      note         = {Dear library team, the grant under which that publication
                      was done is theNORTH-WEST EUROPE INTERREG, grant number NWE
                      639 as part of the IDEA+ project},
      abstract     = {BIOPEP-UWM, a peptide database, contains 5128 peptides from
                      a myriad of resources. Five listed peptides are
                      Angiotensin-I-converting enzyme (ACE-1; EC3.4.15.1)
                      inhibitory peptides derived from a red alga, while two from
                      Chlorella vulgaris have anti-cancer and antioxidative
                      bioactivities. Herein, we describe a process combining
                      hydrolysis with two enzymes, Alcalase and Viscozyme, and
                      filtration to generate protein-rich, bioactive
                      peptide-containing hydrolysates from mixed species of
                      Chlorella sp. and Scenedesmus sp. The potential of generated
                      algal hydrolysates to act as food ingredients was determined
                      by assessment of their techno-functional (foaming,
                      emulsification, solubility, water holding, and oil holding
                      capacity) properties. Bioactive screening of hydrolysates in
                      vitro combined with mass spectrometry (MS) and in silico
                      predictions identified bioactive and functional hydrolysates
                      and six novel peptides. Peptides derived from Chlorella mix
                      have the sequences YDYIGNNPAKGGLF and YIGNNPAKGGLF with
                      predicted anti-inflammatory (medium confidence) and umami
                      potential. Peptides from Scenedesmus mix have sequences
                      IEWYGPDRPKFL, RSPTGEIIFGGETM, TVQIPGGERVPFLF, and
                      IEWYGPDRPKFLGPF with predicted anti-inflammatory,
                      anti-diabetic, and umami attributes. Such microalgal
                      hydrolysates could provide essential amino acids to
                      consumers as well as tertiary health benefits to improve
                      human global health.},
      cin          = {IBG-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39997177},
      UT           = {WOS:001431550200001},
      doi          = {10.3390/md23020053},
      url          = {https://juser.fz-juelich.de/record/1037823},
}