TY  - CHAP
AU  - Choi, Chang-Hoon
AU  - Jayeshkumar Patel, Harshal
AU  - Shah, N. Jon
AU  - Binkofski, Ferdinand
A3  - Mau, Jochen
A3  - Mukhin, Sergey
A3  - Wang, Guanyu
A3  - Xu, Shuhua
TI  - A magnetic resonance spectroscopy approach to quantitatively measure GABA and phosphorus level changes in the primary motor cortex elicited by transcranial direct current stimulation
CY  - Berlin/ Boston
PB  - De Gruyter
M1  - FZJ-2025-01232
SP  - 427-439
PY  - 2024
AB  - AbstractSeveral studies have presented molecular and neurophysiological evidence establishing a connection between synaptic plasticity, specific cognitive functions, energy metabolism, and metabolic syndrome in certain brain areas. As altered plasticity and energy regulation have been associated with neuropsychiatric disorders, studying the neurochemical mechanisms behind neuronal plasticity and energy metabolism simultaneously may support groundbreaking neuroscientific and therapeutic interventions. A favorable approach for investigating neuronal plasticity and energy metabolism is with the use of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that enables the modulation of neuronal excitability and energy in humans. The modulation in excitability and energy is likely mediated by the γ-aminobutyric acid (GABA), which is a potent inhibitor, and high-energy phosphates. Another well-established, non-invasive technique allowing the in vivo examination of the human brain and its functions is magnetic resonance spectroscopy (MRS). MRS is frequently used to quantify the concentration changes of various metabolites at the cellular level in the brain. Although proton-based measurements continue to be the standard, advancements in MRS methodologies and MR hardware have led to the ability to measure variations in neurotransmitters and high-energy phosphates using both proton and phosphorus MRS simultaneously. Owing to the complementary features of both tDCS and MRS, the simultaneous acquisition of data using both modalities offers a promising approach for gathering paired information concerning adaptive synthesis and energy consumption in both healthy and pathologically altered brains. This technique enables access to profound insights into the regulation of brain functions and to model the biochemical plasticity of the motor cortex.
LB  - PUB:(DE-HGF)7
DO  - DOI:10.1515/9783111341996-023
UR  - https://juser.fz-juelich.de/record/1038193
ER  -