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@INBOOK{Mau:1038193,
      author       = {Choi, Chang-Hoon and Jayeshkumar Patel, Harshal and Shah,
                      N. Jon and Binkofski, Ferdinand},
      editor       = {Mau, Jochen and Mukhin, Sergey and Wang, Guanyu and Xu,
                      Shuhua},
      title        = {{A} magnetic resonance spectroscopy approach to
                      quantitatively measure {GABA} and phosphorus level changes
                      in the primary motor cortex elicited by transcranial direct
                      current stimulation},
      address      = {Berlin/ Boston},
      publisher    = {De Gruyter},
      reportid     = {FZJ-2025-01232},
      pages        = {427-439},
      year         = {2024},
      comment      = {BIOKYBERNETIKA / Mau, Jochen (Editor) ; : De Gruyter, 2024,
                      ; ISBN: ; doi:10.1515/9783111341996},
      booktitle     = {BIOKYBERNETIKA / Mau, Jochen (Editor)
                       ; : De Gruyter, 2024, ; ISBN: ;
                       doi:10.1515/9783111341996},
      abstract     = {AbstractSeveral studies have presented molecular and
                      neurophysiological evidence establishing a connection
                      between synaptic plasticity, specific cognitive functions,
                      energy metabolism, and metabolic syndrome in certain brain
                      areas. As altered plasticity and energy regulation have been
                      associated with neuropsychiatric disorders, studying the
                      neurochemical mechanisms behind neuronal plasticity and
                      energy metabolism simultaneously may support groundbreaking
                      neuroscientific and therapeutic interventions. A favorable
                      approach for investigating neuronal plasticity and energy
                      metabolism is with the use of transcranial direct current
                      stimulation (tDCS), a non-invasive brain stimulation
                      technique that enables the modulation of neuronal
                      excitability and energy in humans. The modulation in
                      excitability and energy is likely mediated by the
                      γ-aminobutyric acid (GABA), which is a potent inhibitor,
                      and high-energy phosphates. Another well-established,
                      non-invasive technique allowing the in vivo examination of
                      the human brain and its functions is magnetic resonance
                      spectroscopy (MRS). MRS is frequently used to quantify the
                      concentration changes of various metabolites at the cellular
                      level in the brain. Although proton-based measurements
                      continue to be the standard, advancements in MRS
                      methodologies and MR hardware have led to the ability to
                      measure variations in neurotransmitters and high-energy
                      phosphates using both proton and phosphorus MRS
                      simultaneously. Owing to the complementary features of both
                      tDCS and MRS, the simultaneous acquisition of data using
                      both modalities offers a promising approach for gathering
                      paired information concerning adaptive synthesis and energy
                      consumption in both healthy and pathologically altered
                      brains. This technique enables access to profound insights
                      into the regulation of brain functions and to model the
                      biochemical plasticity of the motor cortex.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1515/9783111341996-023},
      url          = {https://juser.fz-juelich.de/record/1038193},
}