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@ARTICLE{Niklaus:1038495,
      author       = {Niklaus, Stephanie and Glasauer, Stella M. K. and
                      Kovermann, Peter and Farshori, Kulsum F. and Cadetti, Lucia
                      and Früh, Simon and Rieser, Nicolas N. and Gesemann,
                      Matthias and Zang, Jingjing and Fahlke, Christoph and
                      Neuhauss, Stephan C. F.},
      title        = {{G}lutamate transporters are involved in direct inhibitory
                      synaptic transmission in the vertebrate retina},
      journal      = {Open biology},
      volume       = {14},
      number       = {7},
      issn         = {2046-2441},
      address      = {London},
      publisher    = {Royal Society Publishing},
      reportid     = {FZJ-2025-01490},
      pages        = {240140},
      year         = {2024},
      abstract     = {In the central nervous system of vertebrates, glutamate
                      serves as the primary excitatory neurotransmitter. However,
                      in the retina, glutamate released from photoreceptors causes
                      hyperpolarization in post-synaptic ON-bipolar cells through
                      a glutamate-gated chloride current, which seems paradoxical.
                      Our research reveals that this current is modulated by two
                      excitatory glutamate transporters, EAAT5b and EAAT7. In the
                      zebrafish retina, these transporters are located at the
                      dendritic tips of ON-bipolar cells and interact with all
                      four types of cone photoreceptors. The absence of these
                      transporters leads to a decrease in ON-bipolar cell
                      responses, with eaat5b mutants being less severely affected
                      than eaat5b/eaat7 double mutants, which also exhibit altered
                      response kinetics. Biophysical investigations establish that
                      EAAT7 is an active glutamate transporter with a predominant
                      anion conductance. Our study is the first to demonstrate the
                      direct involvement of post-synaptic glutamate transporters
                      in inhibitory direct synaptic transmission at a central
                      nervous system synapse.},
      cin          = {IBI-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project G:(GEPRIS)426950122 - FOR 5046:
                      Integrative Analyse epithelialer SLC26 Anionentransporter
                      – von der molekularen Struktur zur Pathophysiologie
                      (426950122)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)426950122},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1098/rsob.240140},
      url          = {https://juser.fz-juelich.de/record/1038495},
}