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@ARTICLE{Auer:1038539,
      author       = {Auer, Hans and Cabalo, Donna Gift and Rodriguez-Cruces,
                      Raul and Benkarim, Oualid and Paquola, Casey and DeKraker,
                      Jordan and Wang, Yezhou and Valk, Sofie and Bernhardt, Boris
                      C. and Royer, Jessica},
      title        = {{F}rom histology to macroscale function in the human
                      amygdala},
      reportid     = {FZJ-2025-01524},
      year         = {2024},
      note         = {H.A. acknowledges funding from the Fonds de la Recherche du
                      Québec – Nature et Technologie (FRQNT) Master’s
                      Training Scholarship. D.G.C. acknowledges support from
                      FRQ-Sante and Savoy Foundation. J.R. acknowledges support
                      from CIHR. B.C.B. acknowledges support from NSERC, CIHR,
                      SickKids Foundation, BrainCanada, Future Leaders Research
                      Grant, Helmholtz International BigBrain Analytics and
                      Learning Laboratory (HIBALL), Healthy Brains and Healthy
                      Lives, FRQS, and the Canada Research Chairs program.},
      abstract     = {The amygdala is a subcortical region in the mesiotemporal
                      lobe that plays a key role in emotional and sensory
                      functions. Conventional neuroimaging experiments treat this
                      structure as a single, uniform entity, but there is ample
                      histological evidence for subregional heterogeneity in
                      microstructure and function. The current study characterized
                      subregional structure-function coupling in the human
                      amygdala, integrating post mortem histology and in vivo MRI
                      at ultrahigh fields. Core to our work was a novel
                      neuroinformatics approach that leveraged multiscale texture
                      analysis as well as non-linear dimensionality reduction
                      techniques to identify salient dimensions of microstructural
                      variation in a 3D post mortem histological reconstruction of
                      the human amygdala. We observed two axes of subregional
                      variation in this region, describing inferior-superior as
                      well as medio-lateral trends in microstructural
                      differentiation that in part recapitulated established
                      atlases of amygdala subnuclei. Translating our approach to
                      in vivo MRI data acquired at 7 Tesla, we could demonstrate
                      generalizability of these spatial trends across 10 healthy
                      adults. We then cross-referenced microstructural axes with
                      functional blood-oxygen-level dependent (BOLD) signal
                      analysis obtained during task-free conditions, and revealed
                      a close association of structural axes with macroscale
                      functional network embedding, notably the temporo-limbic,
                      default mode, and sensory-motor networks. Our novel
                      multiscale approach consolidates descriptions of amygdala
                      anatomy and function obtained from histological and in vivo
                      imaging techniques.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.07.09.602743},
      url          = {https://juser.fz-juelich.de/record/1038539},
}