%0 Electronic Article
%A Hettwer, Meike D
%A Dorfschmidt, Lena
%A Puhlmann, Lara
%A Jacob, Linda M.
%A Paquola, Casey
%A Bethlehem, Richard A. I.
%A Bullmore, Edward T.
%A Eickhoff, Simon
%A Valk, Sofie
%T Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence
%M FZJ-2025-01527
%D 2024
%X Adolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted consolidation of association cortices. Here, we investigated whether intra-individual trajectories of psychosocial functioning relative to environmental stressor exposure - including adverse life events, dysfunctional family settings, and socio-economic status - are tied to myeloarchitectural maturation and down-stream effects on intrinsic function. To this end, we employed longitudinal myelin-sensitive Magnetic Transfer (MT) and resting-state imaging in the NSPN cohort (aged 14-26y). Developing towards more resilient psychosocial functioning was linked to increasing myelination in the anterolateral prefrontal cortex, which exhibited stabilized functional connectivity. Studying depth-specific intracortical MT profiles and the cortex-wide synchronization of myeloarchitectural maturation, we further observed wide-spread myeloarchitectural re-configuration of association cortices paralleled by attenuated functional reorganization with increasingly resilient outcomes. Together, trajectories of resilient/susceptible psychosocial functioning showed considerable intra-individual change reflected in multi-modal cortical refinement processes at the local and system-level.
%F PUB:(DE-HGF)25
%9 Preprint
%R 10.31234/osf.io/2dv68
%U https://juser.fz-juelich.de/record/1038544