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@ARTICLE{Hettwer:1038544,
      author       = {Hettwer, Meike D and Dorfschmidt, Lena and Puhlmann, Lara
                      and Jacob, Linda M. and Paquola, Casey and Bethlehem,
                      Richard A. I. and Bullmore, Edward T. and Eickhoff, Simon
                      and Valk, Sofie},
      title        = {{L}ongitudinal trajectories of resilient psychosocial
                      functioning link to ongoing cortical myelination and
                      functional reorganization during adolescence},
      reportid     = {FZJ-2025-01527},
      year         = {2024},
      abstract     = {Adolescence is a period of dynamic brain remodeling and
                      susceptibility to psychiatric risk factors, mediated by the
                      protracted consolidation of association cortices. Here, we
                      investigated whether intra-individual trajectories of
                      psychosocial functioning relative to environmental stressor
                      exposure - including adverse life events, dysfunctional
                      family settings, and socio-economic status - are tied to
                      myeloarchitectural maturation and down-stream effects on
                      intrinsic function. To this end, we employed longitudinal
                      myelin-sensitive Magnetic Transfer (MT) and resting-state
                      imaging in the NSPN cohort (aged 14-26y). Developing towards
                      more resilient psychosocial functioning was linked to
                      increasing myelination in the anterolateral prefrontal
                      cortex, which exhibited stabilized functional connectivity.
                      Studying depth-specific intracortical MT profiles and the
                      cortex-wide synchronization of myeloarchitectural
                      maturation, we further observed wide-spread
                      myeloarchitectural re-configuration of association cortices
                      paralleled by attenuated functional reorganization with
                      increasingly resilient outcomes. Together, trajectories of
                      resilient/susceptible psychosocial functioning showed
                      considerable intra-individual change reflected in
                      multi-modal cortical refinement processes at the local and
                      system-level.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.31234/osf.io/2dv68},
      url          = {https://juser.fz-juelich.de/record/1038544},
}