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| Home > Publications database > Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence > print |
| 001 | 1038544 | ||
| 005 | 20250220092007.0 | ||
| 024 | 7 | _ | |a 10.31234/osf.io/2dv68 |2 doi |
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| 037 | _ | _ | |a FZJ-2025-01527 |
| 100 | 1 | _ | |a Hettwer, Meike D |0 P:(DE-Juel1)187157 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence |
| 260 | _ | _ | |c 2024 |
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| 520 | _ | _ | |a Adolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted consolidation of association cortices. Here, we investigated whether intra-individual trajectories of psychosocial functioning relative to environmental stressor exposure - including adverse life events, dysfunctional family settings, and socio-economic status - are tied to myeloarchitectural maturation and down-stream effects on intrinsic function. To this end, we employed longitudinal myelin-sensitive Magnetic Transfer (MT) and resting-state imaging in the NSPN cohort (aged 14-26y). Developing towards more resilient psychosocial functioning was linked to increasing myelination in the anterolateral prefrontal cortex, which exhibited stabilized functional connectivity. Studying depth-specific intracortical MT profiles and the cortex-wide synchronization of myeloarchitectural maturation, we further observed wide-spread myeloarchitectural re-configuration of association cortices paralleled by attenuated functional reorganization with increasingly resilient outcomes. Together, trajectories of resilient/susceptible psychosocial functioning showed considerable intra-individual change reflected in multi-modal cortical refinement processes at the local and system-level. |
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| 700 | 1 | _ | |a Bullmore, Edward T. |0 P:(DE-HGF)0 |b 6 |
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| 700 | 1 | _ | |a Valk, Sofie |0 P:(DE-Juel1)173843 |b 8 |e Corresponding author |
| 773 | _ | _ | |a 10.31234/osf.io/2dv68 |
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| 910 | 1 | _ | |a Institute of Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Max Planck School of Cognition, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Institute of Neuroscience and Medicine, Brain & Behavior (INM-7), Research Centre Jülich, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig |0 I:(DE-HGF)0 |b 8 |6 P:(DE-Juel1)173843 |
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