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@ARTICLE{Kirschner:1038548,
      author       = {Kirschner, Matthias and Hodzic-Santor, Benazir and Kennedy,
                      Leda and Hansen, Justine Y. and Antoniades, Mathilde and
                      Nenadić, Igor and Kircher, Tilo and Krug, Axel and Meller,
                      Tina and Dannlowski, Udo and Grotegerd, Dominik and
                      Flinkenflügel, Kira and Meinert, Susanne and Borgers, Tiana
                      and Goltermann, Janik and Hahn, Tim and Böhnlein, Joscha
                      and Leehr, Elisabeth J. and Barkhau, Carlotta and Fornito,
                      Alex and Arnatkeviciute, Aurina and Bellgrove, Mark A. and
                      Tiego, Jeggan and DeRosse, Pamela and Green, Melissa and
                      Quidé, Yann and Pantelis, Christos and Chan, Raymond and
                      Wang, Yi and Ettinger, Ulrich and Debbané, Martin and
                      Derome, Melodie and Gaser, Christian and Besteher, Bianca
                      and Diederen, Kelly and Spencer, Tom J. and Houenou,
                      Josselin and Pomarol-Clotet, Edith and Salvador, Raymond and
                      Rössler, Wulf and Smigielski, Lukasz and Kumari, Veena and
                      Premkumar, Preethi and Park, Haeme R. P. and Wiebels,
                      Kristina and Lemmers-Jansen, Imke and Gilleen, James and
                      Allen, Paul and Marsman, Jan-Bernard and Lebedeva, Irina and
                      Tomyshev, Alexander and Fett, Anne-Kathrin and Sommer, Iris
                      and Koops, Sanne and Grant, Phillip and Bègue, Indrit and
                      Hernaus, Dennis and Jalbrzikowski, Maria and Paquola, Casey
                      and Larivière, Sara and Bernhardt, Boris and Valk, Sofie
                      and Misic, Bratislav and van Erp, Theo G. M. and Turner,
                      Jessica A. and Thompson, Paul M. and Aleman, Andre and
                      Dagher, Alain and Kaiser, Stefan and Modinos, Gemma},
      title        = {{M}ultiscale characterization of cortical signatures in
                      positive and negative schizotypy: {A} worldwide {ENIGMA}
                      study},
      reportid     = {FZJ-2025-01531},
      year         = {2024},
      abstract     = {Positive and negative schizotypy reflect distinct patterns
                      of subclinical traits in the general population associated
                      with neurodevelopmental and schizophrenia-spectrum
                      pathologies. Yet, a comprehensive characterization of the
                      unique and shared neuroanatomical signatures of these
                      schizotypy dimensions is lacking. Leveraging 3D brain MRI
                      data from 2,730 unmedicated healthy individuals, we
                      identified neuroanatomical profiles of positive and negative
                      schizotypy and systematically compared them to
                      disorder-specific, micro-architectural, connectome, and
                      neurotransmitter-level measures. Positive and negative
                      schizotypy were associated with thinner frontal and thicker
                      paralimbic cortical areas, respectively, and were
                      differentially linked to cortical patterns of
                      schizophrenia-spectrum and neurodevelopmental conditions.
                      Furthermore, these schizotypal cortical patterns mapped onto
                      local attributes of gene expression, cortical myelination,
                      D1 and histamine receptor distributions. Network models
                      identified cortical hub vulnerability to schizotypy-related
                      thickness reduction and epicenters in
                      sensorimotor-to-association and paralimbic areas. This study
                      yields insights into the complex cortical signatures of
                      schizotypy and their relationship to diverse features of
                      cortical organization.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.05.03.24306736},
      url          = {https://juser.fz-juelich.de/record/1038548},
}