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@ARTICLE{Luegering:1038674,
      author       = {Luegering, Anneke and Langner, Robert and Wilm, Stefan and
                      Doeppner, Thorsten R. and Hermann, Dirk M. and Frohnhofen,
                      Helmut and Gronewold, Janine},
      title        = {{A}ssessing self-administration of medication: video-based
                      evaluation of patient performance in the {ABLYMED} study},
      journal      = {Frontiers in medicine},
      volume       = {11},
      issn         = {2296-858X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2025-01639},
      pages        = {1444567},
      year         = {2024},
      abstract     = {Background: Older adults often face challenges in
                      medication management due to multimorbidity and complex
                      medication regimens, which frequently go unreported.
                      Unrecognized problems, however, may lead to a loss of drug
                      efficacy and harmful side effects. This study aimed to
                      quantify the prevalence of such problems by applying a novel
                      video-based assessment procedure in a sample of elderly
                      patients.Methods: In this study, 67 elderly in-patients
                      (≥70 years old and regularly taking ≥5 different drugs
                      autonomously) from the ABLYMED study participated in a
                      placebo-based assessment of medication management with five
                      different dosage forms in an instructed manner while being
                      filmed. Patient performance was quantified by the median
                      value of two raters who evaluated each step of medication
                      administration, which were summed to sum scores for each
                      dosage form and an overall impression for each dosage form
                      with a standardized and previously validated rating
                      scheme.Results: The median (Q1;Q3) sum score for tablets was
                      7.0 (5.0;8.0) with a theoretical range between 4.0 and 17.0,
                      for eye-drops 2.0 (1.0;2.0) with a theoretical range between
                      1.0 and 5.0, for oral drops 4.0 (3.0;6.0) with a theoretical
                      range between 3.0 and 12.0, for pens 7.0 (5.0;9.0) with a
                      theoretical range between 4.0 and 17.0 and for patches 5.0
                      (4.0;7.0) with a theoretical range between 3.0 and 15.0. The
                      most difficult step of medication administration was peeling
                      off the protective liner of a patch: $30\%$ had severe
                      difficulties or it was not possible, $21\%$ had moderate
                      difficulties and $49\%$ had mild or no
                      difficulties.Discussion: In a sample of patients with
                      autonomous medication management, our novel assessment
                      procedure identified a substantial fraction of patients with
                      handling problems for each dosage form. This suggests that
                      patients´ medication management problems should be assessed
                      regularly in clinical routine and tackled by
                      patient-individual training or modification of the
                      prescribed drug regimens to achieve effective drug therapy
                      in the elderly.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39629235},
      UT           = {WOS:001368486400001},
      doi          = {10.3389/fmed.2024.1444567},
      url          = {https://juser.fz-juelich.de/record/1038674},
}