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@PHDTHESIS{Kasper:1038908,
      author       = {Kasper, Jan},
      title        = {{A}nalyse der {A}uswirkungen von {A}lterung,
                      {N}eurodegeneration und {D}epression auf die mittels
                      {M}agnetresonanztomographie gemessene {H}irnfunktion},
      school       = {HHU Düsseldorf},
      type         = {Dissertation},
      reportid     = {FZJ-2025-01716},
      pages        = {192},
      year         = {2024},
      note         = {Dissertation, HHU Düsseldorf, 2024},
      abstract     = {In recent decades, the scientific community has made
                      progress in mapping the functionalorganization of the human
                      brain. Functional alterations in the typical aging process
                      and in severalneurodegenerative diseases, as well as their
                      pathological pathways, have been identified. However,many
                      underlying (patho-)mechanisms remain unclear, the knowledge
                      of which could pave the wayfor new diagnostic biomarkers and
                      therapeutical targets. Multimodal associations, such as
                      spatialcorrelations (co-localizations) between neurochemical
                      properties and alterations in brain function orstructure,
                      provide insights into biological entities that may be
                      particularly affected by the agingprocess or related
                      neurological diseases. Additionally, such associations
                      themselves could serve asdiagnostic or prognostic biomarkers
                      for brain diseases. In contrast to neurological diseases,
                      theeffects of psychiatric diseases such as depression on the
                      functional organization of the brain have notyet been
                      conclusively clarified, which is partly due to the
                      heterogeneity of the clinical picture. Withthe help of large
                      data sets, this obstacle could be overcome and changes in
                      the brain could be mappedin a level of detail that has not
                      yet been achieved in studies with smaller sample sizes. In
                      the threestudies presented here, data from resting-state
                      functional magnetic resonance imaging (resting-statefMRI)
                      were used to investigate the regional characteristics of
                      age-related typical and pathologicalbrain alterations in
                      people with Huntington’s disease, Parkinson’s disease,
                      and experience ofdepression. In the first two studies, the
                      local functional alterations in the typical aging process
                      and intwo neurodegenerative diseases were mapped.
                      Associations of these alterations with other neuronaland
                      clinical data provided indications of potential particularly
                      vulnerable cells and biomarkers ofdisease severity. In the
                      third study, we examined how various criteria of experienced
                      depression affectbrain function and structure and identified
                      the criteria most strongly associated with brain
                      alterations.The results suggested specific neurochemical
                      properties that may influence neuronal alterations
                      indifferent conditions, aiding our understanding of the
                      studied neurodegenerative diseases and agingprocesses, and
                      potentially supporting the future development of new
                      pharmacotherapies. Depressioncriteria that were identified
                      as most strongly associated with functional changes may
                      indicate apersistent effect of depression or its treatment
                      on brain function and should be considered whenplanning
                      future studies on depression.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.34734/FZJ-2025-01716},
      url          = {https://juser.fz-juelich.de/record/1038908},
}