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001039808 1001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b0$$eCorresponding author
001039808 245__ $$aAuthor Correction: The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow
001039808 260__ $$aNew York, NY$$bNature America$$c2025
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001039808 520__ $$aThe default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem histology and in vivo neuroimaging to characterize the anatomy of the DMN to better understand its role in information processing and cortical communication. Our results show that the DMN is cytoarchitecturally heterogenous, containing cytoarchitectural types that are variably specialized for unimodal, heteromodal and memory-related processing. Studying diffusion-based structural connectivity in combination with cytoarchitecture, we found the DMN contains regions receptive to input from sensory cortex and a core that is relatively insulated from environmental input. Finally, analysis of signal flow with effective connectivity models showed that the DMN is unique amongst cortical networks in balancing its output across the levels of sensory hierarchies. Together, our study establishes an anatomical foundation from which accounts of the broad role the DMN plays in human brain function and cognition can be developed.
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001039808 536__ $$0G:(EU-Grant)945539$$aHBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)$$c945539$$fH2020-SGA-FETFLAG-HBP-2019$$x2
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001039808 7001_ $$0P:(DE-HGF)0$$aGarber, Margaret$$b1
001039808 7001_ $$0P:(DE-HGF)0$$aFrässle, Stefan$$b2
001039808 7001_ $$0P:(DE-HGF)0$$aRoyer, Jessica$$b3
001039808 7001_ $$0P:(DE-HGF)0$$aZhou, Yigu$$b4
001039808 7001_ $$0P:(DE-HGF)0$$aTavakol, Shahin$$b5
001039808 7001_ $$0P:(DE-HGF)0$$aRodriguez-Cruces, Raul$$b6
001039808 7001_ $$0P:(DE-HGF)0$$aCabalo, Donna Gift$$b7
001039808 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie$$b8
001039808 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b9
001039808 7001_ $$0P:(DE-HGF)0$$aMargulies, Daniel S.$$b10
001039808 7001_ $$0P:(DE-HGF)0$$aEvans, Alan$$b11
001039808 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b12$$ufzj
001039808 7001_ $$0P:(DE-HGF)0$$aJefferies, Elizabeth$$b13
001039808 7001_ $$0P:(DE-HGF)0$$aSmallwood, Jonathan$$b14
001039808 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b15
001039808 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-025-01900-x$$p688$$tNature neuroscience$$v28$$x1097-6256$$y2025
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