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@ARTICLE{Reimann:1040282,
      author       = {Reimann, Gerion and Hoseini, Alireza and Koçak, Mihrican
                      and Beste, Melissa and Küppers, Vincent and Rosenzweig,
                      Ivana and Elmenhorst, David and Pires, Gabriel Natan and
                      Laird, Angela R. and Fox, Peter T. and Spiegelhalder, Kai
                      and Reetz, Kathrin and Eickhoff, Simon and Müller, Veronika
                      and Tahmasian, Masoud},
      title        = {{D}istinct convergent brain alterations in sleep disorders
                      and sleep deprivation},
      journal      = {JAMA psychiatry},
      volume       = {82},
      number       = {7},
      issn         = {2168-622X},
      address      = {Chicago, Ill.},
      publisher    = {AMA},
      reportid     = {FZJ-2025-01821},
      pages        = {681-691},
      year         = {2025},
      abstract     = {Importance Sleep disorders have different etiologies yet
                      share some nocturnal and daytime symptoms, suggesting common
                      neurobiological substrates; healthy individuals undergoing
                      experimental sleep deprivation also report analogous daytime
                      symptoms. However, brain similarities and differences
                      between long-term sleep disorders and short-term sleep
                      deprivation are unclear.Objective To investigate the shared
                      and specific neural correlates across sleep disorders and
                      sleep deprivation.Data Sources PubMed, Web of Science,
                      Embase, Scopus, and BrainMap were searched up to January
                      2024 to identify relevant structural and functional
                      neuroimaging articles.Study Selection Whole-brain
                      neuroimaging articles reporting voxel-based group
                      differences between patients with different sleep disorders
                      and healthy control participants or between total or partial
                      sleep-deprived and well-rested individuals were
                      included.Data Extraction and Synthesis Significant
                      coordinates of group comparisons, their contrast direction
                      (eg, patients < controls), and imaging modality were
                      extracted. For each article, 2 raters independently
                      evaluated eligibility and extracted data. Subsequently,
                      several meta-analyses were performed with the revised
                      activation likelihood estimation algorithm using P < .05
                      cluster-level familywise error correction.Main Outcomes and
                      Measures Transdiagnostic regional brain alterations were
                      identified across sleep disorders and among articles
                      reporting sleep deprivation. Their associated behavioral
                      functions and task-based or task-free connectivity patterns
                      were explored using 2 independent datasets (BrainMap and the
                      enhanced Nathan Kline Institute–Rockland Sample).Results A
                      total of 231 articles (140 unique experiments, 3380 unique
                      participants) were retrieved. The analysis across sleep
                      disorders (n = 95 experiments) identified the subgenual
                      anterior cingulate cortex (176 voxels, z score = 4.86),
                      associated with reward, reasoning, and gustation, and the
                      amygdala and hippocampus (130 voxels, z score = 4.00),
                      associated with negative emotion processing, memory, and
                      olfaction. Both clusters had positive functional
                      connectivity with the default mode network. The right
                      thalamus (153 voxels, z score = 5.21) emerged as a
                      consistent regional alteration following sleep deprivation
                      (n = 45 experiments). This cluster was associated with
                      thermoregulation, action, and pain perception and showed
                      positive functional connectivity with subcortical and
                      (pre)motor regions. Subanalyses regarding the direction of
                      alterations demonstrated that the subgenual anterior
                      cingulate cortex exhibited decreased activation,
                      connectivity, and/or volume, while the amygdala and
                      hippocampus cluster and the thalamus cluster demonstrated
                      increased activation, connectivity, and/or
                      volume.Conclusions and Relevance Distinct convergent brain
                      abnormalities were observed between long-term sleep
                      disorders (probably reflecting shared symptoms) and
                      short-term sleep deprivation.},
      cin          = {INM-7 / INM-2 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-11-20170113},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40266625},
      UT           = {WOS:001475868100001},
      doi          = {10.1001/jamapsychiatry.2025.0488},
      url          = {https://juser.fz-juelich.de/record/1040282},
}