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@ARTICLE{Nachmias:1040322,
      author       = {Nachmias, Dikla and Frohn, Béla P. and Sachse, Carsten and
                      Mizrahi, Itzhak and Elia, Natalie},
      title        = {{ESCRT}s – a multi-purpose membrane remodeling device
                      encoded in all life forms},
      journal      = {Trends in microbiology},
      volume       = {1},
      number       = {2 2025},
      issn         = {0966-842X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2025-01836},
      pages        = {S0966842X25000083},
      year         = {2025},
      abstract     = {The ESCRT (endosomal sorting complexes required for
                      transport) membrane remodeling complex, found across all
                      life forms, exhibits a versatility that transcends
                      evolutionary boundaries. From orchestrating the constriction
                      of micron-wide tubes in cell division to facilitating the
                      budding of 50 nm vesicles in receptor degradation, ESCRTs
                      perform diverse functions in animal cells. However, the
                      basis of this functional diversity remains enigmatic. While
                      extensively studied in eukaryotes, the role of ESCRTs in
                      prokaryotes is only beginning to emerge. This review
                      synthesizes data on ESCRT systems across the tree of life,
                      focusing on microorganisms and drawing parallels to their
                      functions in human cells. This comparative approach
                      highlights the remarkable plasticity of the ESCRT system
                      across functional, structural, and genomic levels in both
                      prokaryotes and eukaryotes. This integrated knowledge
                      supports a model in which the ESCRT system evolved as a
                      multipurpose membrane remodeling tool, adaptable to specific
                      functions within and across organisms. Our review not only
                      underscores the significance of ESCRTs in microorganisms but
                      also paves the way for exciting avenues of research into the
                      intricacies of cellular membrane dynamics, offering valuable
                      insights into the evolution of cellular complexity across
                      diverse organisms and ecosystems.},
      cin          = {ER-C-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.tim.2025.01.009},
      url          = {https://juser.fz-juelich.de/record/1040322},
}