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@ARTICLE{Vossel:1040600,
      author       = {Vossel, Simone and Käsbauer, Anne-Sophie and Mengotti,
                      Paola and Schmidt, Claudia C. and Saliger, Jochen and Karbe,
                      Hans and Fink, Gereon R.},
      title        = {{N}eglect symptoms are related to a
                      prediction-hypersensitivity in ipsilesional space},
      journal      = {Cortex},
      volume       = {184},
      issn         = {0010-9452},
      address      = {Paris},
      publisher    = {Elsevier Masson},
      reportid     = {FZJ-2025-01949},
      pages        = {1 - 18},
      year         = {2025},
      abstract     = {The precise cognitive mechanisms underlying spatial neglect
                      are not fully understood. Recent studies have provided the
                      first evidence for aberrant behavioral and
                      electrophysiological prediction and prediction error
                      responses in patients with neglect, but also in
                      right-hemispheric (RH) stroke patients without neglect. For
                      prediction-dependent attention, as assessed with Posner-type
                      cueing paradigms with volatile cue-target contingencies,
                      studies in healthy volunteers point to a crucial role of the
                      right temporo-parietal junction (rTPJ) – as part of a
                      network commonly disrupted in neglect. In order to study
                      altered prediction-dependent attention in patients with RH
                      damage and neglect, the present study employed a spatial
                      cueing paradigm with unsignalled changes in the cue’s
                      predictive value in 26 RH patients, 21 left-hemispheric (LH)
                      patients, and 33 healthy elderly controls. The inference of
                      the changing cue’s predictive value was assessed with a
                      Rescorla-Wagner learning model of response times (RTs) and
                      participants' ratings. We tested for lesion-side-dependent
                      relationships between the computational model parameters,
                      ratings, and neuropsychological performance. Moreover, we
                      investigated links between the behavioral signatures of
                      predictive processing and lesion anatomy (lesion location
                      and disconnection). The results provided no evidence for a
                      predictive inference deficit, but revealed a correlation
                      between a hypersensitivity of RTs to inferred predictions
                      for ipsilesional stimuli and neglect symptoms in RH
                      patients. Irrespective of symptoms of neglect, the rating of
                      the cue’s predictive value deviated more from the actual
                      values in RH patients. RT hypersensitivity for ipsilesional
                      targets was linked to disconnection within fronto-parietal,
                      fronto-occipital, and temporo-parietal pathways. These
                      findings provide novel insights into the role of altered
                      prediction-dependent processing for neglect as assessed by
                      different read-outs, highlighting an exaggerated response
                      adaption to predictions of ipsilesional stimuli.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)491111487 -
                      Open-Access-Publikationskosten / 2025 - 2027 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487) / DFG
                      project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)491111487 /
                      G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39787718},
      UT           = {WOS:001412584500001},
      doi          = {10.1016/j.cortex.2024.12.007},
      url          = {https://juser.fz-juelich.de/record/1040600},
}