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@ARTICLE{Desai:1040653,
      author       = {Desai, Sunil and Bhalani, Deep and Ray, Debes and Aswal,
                      Vinod K. and Pillai, Sadafara A.},
      title        = {{E}xploring dilution effects on {P}luronic® {P}103
                      micelles: {S}tructural insights},
      journal      = {Journal of molecular liquids},
      volume       = {419},
      issn         = {0167-7322},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2025-01987},
      pages        = {126779 -},
      year         = {2025},
      abstract     = {The study examines the impact of dilution on the stability
                      of Pluronic® P103 micelles. It thoroughly explores the
                      consequences of dilution on micellar size, providing
                      essential insights into their behavior under physiological
                      conditions. The salt and polymer concentrations were
                      simultaneously varied at different ratios to analyze their
                      effects. Techniques such as cloud point, small-angle neutron
                      scattering (SANS), dynamic light scattering (DLS), Fourier
                      transform infrared (FTIR) spectroscopy and high-performance
                      liquid chromatography (HPLC) were employed to check the
                      influence of dilution on the phase behaviour, size and
                      structure of micellar self-assembly, interaction and
                      encapsulation efficiency for the hydrophobic
                      anti-inflammatory drug, ibuprofen, respectively. The results
                      showed that increased polymer and salt concentration led to
                      synergistic effects influencing nanostructure formation. The
                      presence of salt significantly influences micellar size, and
                      the encapsulation potential of the micelles for the drug.
                      This study enhances our fundamental understanding of these
                      polymer-salt systems and has potential implications for
                      tailoring nanostructures with precise control over their
                      properties. These findings are significant in drug delivery
                      and materials science fields, offering opportunities for
                      designing customized nanostructures for various
                      applications.},
      cin          = {IBI-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.molliq.2024.126779},
      url          = {https://juser.fz-juelich.de/record/1040653},
}