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@ARTICLE{Brouzou:1041135,
      author       = {Brouzou, Katia Ourania and Kamp, Daniel and Hensel, Lukas
                      and Lüdtke, Jana and Lahnakoski, Juha M. and Dukart,
                      Jürgen and Mikus, Nace and Mathys, Christoph and Eickhoff,
                      Simon B. and Schilbach, Leonhard},
      title        = {{U}sing personalised brain stimulation to modulate social
                      cognition in adults with autism-spectrum-disorder: protocol
                      for a randomised single-blind r{TMS} study},
      journal      = {BMC psychiatry},
      volume       = {25},
      number       = {1},
      issn         = {1471-244X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2025-02163},
      pages        = {281},
      year         = {2025},
      abstract     = {BackgroundAutism spectrum disorder (ASD) is a
                      neurodevelopmental disorder characterized by impairments of
                      social interaction and communication as well as repetitive,
                      stereotyped behaviour. Previous research indicates that ASD
                      without intellectual impairment is associated with
                      underactivity and reduced functional connectivity of the
                      brain’s mentalizing pathway, to which the right
                      temporo-parietal junction (rTPJ) serves as an important
                      entry point and hub. In this study, we aim to utilize
                      functional magnetic resonance imaging (fMRI) to localize
                      activation maxima in the rTPJ and other regions involved in
                      social cognition to generate individualized targets for
                      neuro-navigated, intermittent theta burst stimulation (iTBS)
                      in order to modulate brain activity in a region centrally
                      engaged in social information processing.MethodsIn this
                      single-blind, randomized, between-subject
                      neuroimaging-guided brain stimulation study we plan to
                      recruit 52 participants with prediagnosed ASD and 52
                      controls without ASD aged between 18 and 65 years.
                      Participants will be classified into two groups and will
                      randomly receive one session of either verum- or sham-iTBS.
                      Effects will be assessed by using well-established
                      experimental tasks that interrogate social behaviour, but
                      also use computational modelling to investigate brain
                      stimulation effects at this level.DiscussionThis study aims
                      to use personalized, non-invasive brain stimulation to alter
                      social information processing in adults with and without
                      high-functioning ASD, which has not been studied before with
                      a similar protocol or a sample size of this magnitude. By
                      doing so in combination with behavioural and computational
                      tasks, this study has the potential to provide new
                      mechanistic insights into the workings of the social brain.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40133861},
      UT           = {WOS:001452642200005},
      doi          = {10.1186/s12888-025-06719-1},
      url          = {https://juser.fz-juelich.de/record/1041135},
}