001041316 001__ 1041316
001041316 005__ 20250414120449.0
001041316 0247_ $$2doi$$a10.1007/s00415-025-12931-6
001041316 0247_ $$2ISSN$$a0367-004X
001041316 0247_ $$2ISSN$$a0012-1037
001041316 0247_ $$2ISSN$$a0340-5354
001041316 0247_ $$2ISSN$$a1432-1459
001041316 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-02215
001041316 0247_ $$2pmid$$a39934559
001041316 0247_ $$2WOS$$aWOS:001419949200007
001041316 037__ $$aFZJ-2025-02215
001041316 082__ $$a610
001041316 1001_ $$00000-0001-5858-7762$$aOphey, Anja$$b0$$eCorresponding author
001041316 245__ $$aAccelerometry-derived features of physical activity, sleep and circadian rhythm relate to non-motor symptoms in individuals with isolated REM sleep behavior disorder
001041316 260__ $$a[Darmstadt]$$bSteinkopff$$c2025
001041316 3367_ $$2DRIVER$$aarticle
001041316 3367_ $$2DataCite$$aOutput Types/Journal article
001041316 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1744287758_30327
001041316 3367_ $$2BibTeX$$aARTICLE
001041316 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001041316 3367_ $$00$$2EndNote$$aJournal Article
001041316 500__ $$aFunding Open Access funding enabled and organized by Projekt DEAL
001041316 520__ $$aAccelerometry enables passive, continuous, high-frequency monitoring under free-living conditions. For individuals with isolated REM sleep behavior disorder (iRBD), a potential prodromal phase of Parkinson's disease (PD) and dementia with Lewy bodies, accelerometry has been primarily applied to aid diagnosis and to assess phenoconversion risk. To extend this knowledge, we cross-sectionally combined clinical assessments focusing on non-motor symptoms with accelerometry-derived features of physical activity (PA), sleep, and circadian rhythm of N = 68 individuals with iRBD (age: 69.48 ± 6.01 years, self-reported RBD symptom duration: 9.46 ± 6.21 years, 85 % male). Accelerometry-assessed PA was associated with more stable circadian rhythms. Additionally, higher PA and more stable circadian rhythms were linked to a lower burden of overall non-motor symptoms, depressive symptoms, and fatigue with small to moderate effect sizes. Furthermore, including accelerometry-derived features improved the prediction of individual clinical scores, particularly for cognitive performance. Our findings contribute to the growing body of evidence highlighting the complex interplay between PA, sleep, circadian rhythm, and non-motor symptoms in α-synucleinopathies. Future research should focus on longitudinal studies to monitor changes in clinical outcomes and digital biomarkers over time to enhance our understanding of symptom progression and corresponding lifestyle changes in prodromal and manifest α-synucleinopathies.Keywords: Actigraphy; Digital biomarkers; Digital health technology; Prodromal Parkinson’s disease; Wearables.
001041316 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001041316 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001041316 7001_ $$00000-0002-2951-2208$$aVinod, Vaishali$$b1
001041316 7001_ $$0P:(DE-Juel1)194632$$aRöttgen, Sinah$$b2
001041316 7001_ $$00000-0003-2781-3143$$aScharfenberg, Daniel$$b3
001041316 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b4
001041316 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b5
001041316 7001_ $$00000-0001-8603-2545$$aKalbe, Elke$$b6
001041316 7001_ $$00000-0002-5945-4694$$aMaetzler, Walter$$b7
001041316 7001_ $$00000-0003-4813-3868$$aHansen, Clint$$b8
001041316 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-025-12931-6$$gVol. 272, no. 3, p. 201$$n3$$p201$$tJournal of neurology$$v272$$x0367-004X$$y2025
001041316 8564_ $$uhttps://juser.fz-juelich.de/record/1041316/files/PDF.pdf$$yOpenAccess
001041316 909CO $$ooai:juser.fz-juelich.de:1041316$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001041316 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)194632$$aForschungszentrum Jülich$$b2$$kFZJ
001041316 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b4$$kFZJ
001041316 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)179044$$aForschungszentrum Jülich$$b5$$kFZJ
001041316 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001041316 9141_ $$y2025
001041316 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001041316 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROL : 2022$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2024-12-10$$wger
001041316 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ NEUROL : 2022$$d2024-12-10
001041316 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-10
001041316 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
001041316 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2024-12-10$$wger
001041316 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-10
001041316 920__ $$lyes
001041316 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
001041316 980__ $$ajournal
001041316 980__ $$aVDB
001041316 980__ $$aUNRESTRICTED
001041316 980__ $$aI:(DE-Juel1)INM-3-20090406
001041316 9801_ $$aFullTexts