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| 100 | 1 | _ | |a Friedrich, Michel |0 P:(DE-Juel1)184842 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Functional connectivity between tumor region and resting-state networks as imaging biomarker for overall survival in recurrent gliomas diagnosed by O -(2-[18F]fluoroethyl)- l -tyrosine PET |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford University Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a This open-access publication is funded by the DeutscheForschungsgemeinschaft (DFG, German Research Foundation,contract number 491111487). |
| 520 | _ | _ | |a BackgroundAmino acid PET using the tracer O-(2-[18F]fluoroethyl)-l-tyrosine (FET) is one of the most reliable imaging methods for detecting glioma recurrence. Here, we hypothesized that functional MR connectivity between the metabolic active recurrent tumor region and resting-state networks of the brain could serve as a prognostic imaging biomarker for overall survival (OS).MethodsThe study included 82 patients (26–81 years; median Eastern Cooperative Oncology Group performance score, 0) with recurrent gliomas following therapy (WHO-CNS 2021 grade 4 glioblastoma, n = 57; grade 3 or 4 astrocytoma, n = 12; grade 2 or 3 oligodendroglioma, n = 13) diagnosed by FET PET simultaneously acquired with functional resting-state MR. Functional connectivity (FC) was assessed between tumor regions and 7 canonical resting-state networks.ResultsWHO tumor grade and IDH mutation status were strong predictors of OS after recurrence (P < .001). Overall FC between tumor regions and networks was highest in oligodendrogliomas and was inversely related to tumor grade (P = .031). FC between the tumor region and the dorsal attention network was associated with longer OS (HR, 0.88; 95%CI, 0.80–0.97; P = .007), and showed an independent association with OS (HR, 0.90; 95%CI, 0.81–0.99; P = .033) in a model including clinical factors, tumor volume and MGMT. In the glioblastoma subgroup, tumor volume and FC between the tumor and the visual network (HR, 0.90; 95%CI, 0.82–0.99, P = .031) were independent predictors of survival.ConclusionsRecurrent gliomas exhibit significant FC to resting-state networks of the brain. Besides tumor type and grade, high FC between the tumor and distinct networks could serve as independent prognostic factors for improved OS in these patients. |
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| 536 | _ | _ | |a DFG project G:(GEPRIS)491111487 - Open-Access-Publikationskosten / 2025 - 2027 / Forschungszentrum Jülich (OAPKFZJ) (491111487) |0 G:(GEPRIS)491111487 |c 491111487 |x 1 |
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| 700 | 1 | _ | |a Werner, Jan-Michael |0 0000-0001-7147-4594 |b 1 |
| 700 | 1 | _ | |a Steinbach, Joachim P |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Sabel, Michael |0 P:(DE-Juel1)165921 |b 3 |
| 700 | 1 | _ | |a Herrlinger, Ulrich |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Piroth, Marc |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Stoffels, Gabriele |0 P:(DE-Juel1)131627 |b 6 |
| 700 | 1 | _ | |a Filss, Christian P |0 P:(DE-Juel1)141877 |b 7 |
| 700 | 1 | _ | |a Lohmann, Philipp |0 P:(DE-Juel1)145110 |b 8 |
| 700 | 1 | _ | |a Shah, Nadim J |0 P:(DE-Juel1)131794 |b 9 |
| 700 | 1 | _ | |a Ruge, Maximilian I |0 P:(DE-HGF)0 |b 10 |
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| 700 | 1 | _ | |a Goldbrunner, Roland |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Langen, Karl-Josef |0 P:(DE-Juel1)131777 |b 13 |
| 700 | 1 | _ | |a Fink, Gereon R |0 P:(DE-Juel1)131720 |b 14 |
| 700 | 1 | _ | |a Kocher, Martin |0 P:(DE-Juel1)173675 |b 15 |
| 700 | 1 | _ | |a Galldiks, Norbert |0 P:(DE-Juel1)143792 |b 16 |
| 773 | _ | _ | |a 10.1093/noajnl/vdaf023 |g Vol. 7, no. 1, p. vdaf023 |0 PERI:(DE-600)3009682-0 |n 1 |p vdaf023 |t Neuro-oncology advances |v 7 |y 2025 |x 2632-2498 |
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