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@ARTICLE{Primus:1041614,
      author       = {Primus, Sabrina and Hoffstaedter, Felix and Raimondo,
                      Federico and Eickhoff, Simon and Winkelmann, Juliane and
                      Oexle, Konrad and Patil, Kaustubh},
      title        = {{B}eyond {V}olume: {U}nraveling the {G}enetics of {H}uman
                      {B}rain {G}eometry},
      journal      = {Science advances},
      volume       = {11},
      number       = {24},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {FZJ-2025-02348},
      pages        = {-},
      year         = {2025},
      abstract     = {Brain geometry affects brain function. A quantitative
                      encoding of form is provided by the Laplace-Beltrami
                      operator’s spectrum of eigenvalues (LBS). We examined LBS
                      genetics of 22 subcortical brain structures and cerebellum
                      in 19,862 healthy White-British UK Biobank participants by
                      multivariate genome-wide association study on the first 49
                      eigenvalues each. Controlling for surface and volume, we
                      identified 80 unique variants influencing the shapes of one
                      or several structures, with the highest yield (37 variants)
                      for brain stem. The previously known influence of several of
                      these loci on basic morphology, such as volume, is thus
                      shown to also influence complex shape. Known associations of
                      observed loci with blood pressure, neurodegeneration,
                      alcohol consumption, and mental disorders hint at
                      preclinical stages of these conditions potentially mediating
                      the genetic effect on brain morphology. Significant
                      correlations between LBS of several brain structures and the
                      polygenic risks of hypertension, ischemic stroke, and
                      schizophrenia evince brain shapes as early biomarkers.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40512868},
      UT           = {WOS:001508114400004},
      doi          = {10.1126/sciadv.adr1644},
      url          = {https://juser.fz-juelich.de/record/1041614},
}