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@INPROCEEDINGS{Behle:1043302,
      author       = {Behle, Eric and Herold, J. M. and Schug, Alexander},
      title        = {{S}imulating tumor-induced angiogenesis using {C}ells in
                      {S}ilico},
      reportid     = {FZJ-2025-02823},
      year         = {2024},
      abstract     = {Cancer remains an inadequately understood ailment affecting
                      humanity. Its treatment poses a challenge due to tumor
                      variability and a tumor’s impact on the surrounding
                      environment. Tumor-induced angiogenesis is a concerning
                      aspect of the disease. Here, a hypoxic tumor secretes growth
                      factors, which prompts nearby blood vessel branching and
                      successive growth toward the tumor. To study this process on
                      a computational level, we turned to Cells in Silico (CiS), a
                      high performance framework for large-scale tissue simulation
                      previously developed by us. Combining a cellular Potts model
                      and an agent-based layer, CiS is capable of simulating
                      tissues composed of tens of millions of cells, while
                      accurately representing many physical and biological
                      properties. Our ultimate objective is to construct a
                      cellular digital twin of a tumor, and integrating a
                      realistically evolving nutrient environment is crucial.
                      Hence, we have implemented tumor-induced blood vessel growth
                      into CiS, and have studied the behavior of tumors placed in
                      different environments. With this we aim to explore
                      questions regarding hot spots for tumor growth within the
                      body.},
      month         = {Mar},
      date          = {2024-03-17},
      organization  = {DPG Spring Meeting 2024, Berlin
                       (Germany), 17 Mar 2024 - 22 Mar 2024},
      subtyp        = {After Call},
      cin          = {JSC},
      cid          = {I:(DE-Juel1)JSC-20090406},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / PhD no Grant -
                      Doktorand ohne besondere Förderung (PHD-NO-GRANT-20170405)},
      pid          = {G:(DE-HGF)POF4-5111 / G:(DE-Juel1)PHD-NO-GRANT-20170405},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/1043302},
}