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@ARTICLE{Akradi:1043580,
      author       = {Akradi, Mohammad and Farzane-Daghigh, Tara and Ebneabbasi,
                      Amir and Bi, Hanwen and Drzezga, Alexander and Mander, Bryce
                      A. and Eickhoff, Simon B. and Tahmasian, Masoud},
      title        = {{H}ow is self-reported sleep-disordered breathing linked
                      with biomarkers of {A}lzheimer’s disease?},
      journal      = {Neurobiology of aging},
      volume       = {154},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2025-02937},
      pages        = {16-24},
      year         = {2025},
      note         = {Data collection and sharing for this project was funded by
                      the Alzheimer's Disease Neuroimaging Initiative (ADNI)
                      (National Institutes of Health Grant U01 AG024904) and DOD
                      ADNI (Department of Defense award number
                      W81XWH-12–2–0012). ADNI is funded by the National
                      Institute on Aging, the National Institute of Biomedical
                      Imaging and Bioengineering, and through generous
                      contributions from the following: AbbVie, Alzheimer's
                      Association; Alzheimer's Drug Discovery Foundation; Araclon
                      Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb
                      Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan
                      Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F.
                      Hoffmann-La Roche Ltd and its affiliated company Genentech,
                      Inc.; Fujirebio; GE Healthcare; IXICO Ltd.;Janssen Alzheimer
                      Immunotherapy Research $\&$ Development, LLC.; Johnson $\&$
                      Johnson Pharmaceutical Research $\&$ Development LLC.;
                      Lumosity; Lundbeck; Merck $\&$ Co., Inc.;Meso Scale
                      Diagnostics, LLC.; NeuroRx Research; Neurotrack
                      Technologies; Novartis Pharmaceuticals Corporation; Pfizer
                      Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical
                      Company; and Transition Therapeutics. The Canadian
                      Institutes of Health Research is providing funds to support
                      ADNI clinical sites in Canada. Private sector contributions
                      are facilitated by the Foundation for the National
                      Institutes of Health (www.fnih.org). The grantee
                      organization is the Northern California Institute for
                      Research and Education, and the study is coordinated by the
                      Alzheimer's Therapeutic Research Institute at the University
                      of Southern California. ADNI data are disseminated by the
                      Laboratory for Neuro Imaging at the University of Southern
                      California. Author SBE received Helmholtz Imaging Platform
                      grant (NimRLS, ZT-I-PF-4–010). Author BM currently serves
                      on a scientific advisory board for AstronauTx.},
      abstract     = {Sleep-disordered breathing (SDB) is prevalent in
                      Alzheimer’s disease (AD). Here, we assessed how
                      self-reported SDB is linked with AD biomarkers, including
                      amyloid-beta plaque burden (Aβ), regional
                      fluorodeoxyglucose uptake (rFDG-PET), grey matter volume
                      (GMV), cognitive scores, and cerebrospinal fluid (CSF)
                      biomarkers. We selected 757 individuals, including AD, mild
                      cognitive impairment (MCI), and cognitively unimpaired (CU)
                      groups, and divided them according to self-reported SDB
                      condition. Using a stratified subsampling approach, we
                      selected 512 matched subsamples, and effect sizes (ES) of
                      the group-SDB interaction were computed for each biomarker
                      and cognitive score across subsamples. Linear regression
                      assessed associations between the ES of Aβ, rFDG, and GMV
                      with the ES of cognitive scores and CSF biomarkers. The
                      group-SDB interaction had a medium-sized effect on Aβ,
                      rFDG, and GMV biomarkers in several brain areas.
                      Participants with SDB exhibited reduced Aβ burden and
                      increased rFDG uptake in the CU and MCI groups, whereas the
                      AD group showed elevated Aβ burden and decreased rFDG.
                      Additionally, SDB+ individuals demonstrated GMV
                      alterations across all groups. The ES of group-SDB
                      interaction on Aβ in the precuneus, middle temporal gyrus,
                      and fusiform gyrus was associated with the ES of cognitive
                      scores. Taken together, we observed a robust association of
                      SDB with Aβ pathology in PET and CSF relative to rFDG and
                      GMV in the AD group, which was also associated with
                      cognitive decline.},
      cin          = {INM-7 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40582243},
      UT           = {WOS:001527114100001},
      doi          = {10.1016/j.neurobiolaging.2025.06.006},
      url          = {https://juser.fz-juelich.de/record/1043580},
}