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@ARTICLE{Artmann:1043688,
      author       = {Artmann, Gerhard M. and Weiergräber, Oliver H. and
                      Damiati, Samar and Firat, Ipek Seda and Artmann, Aysegül
                      Temiz},
      title        = {{T}he molecular origin of body temperature in homeothermic
                      species},
      journal      = {American journal of physiology / Regulatory, integrative
                      and comparative physiology},
      volume       = {329},
      number       = {4},
      issn         = {0363-6119},
      address      = {Bethesda, Md.},
      publisher    = {American Physiological Society},
      reportid     = {FZJ-2025-02986},
      pages        = {R509-R597},
      year         = {2025},
      abstract     = {We propose the Interfacial Water Quantum-transition model
                      (IWQ model) as a novel paradigm explaining
                      temperature-dependent structural and functional transitions
                      (discontinuities) observed in proteins. The central
                      postulate states that experimentally measured critical
                      temperatures, TC, are related to physical reference
                      temperatures, TW, defined by rotational quantum transitions
                      of temporarily free water molecules in the protein-water
                      interface. Applicability of this concept is demonstrated
                      using transitions observed in two disparate model systems,
                      viz., hemoglobin and thermosensitive TRP channels. We
                      propose that the same mechanism underlies the definition of
                      basal body temperatures in homeotherms, the reference
                      temperature for humans being TW=36.32°C. Specifically, we
                      demonstrate that the body temperatures of both human and
                      chicken (representing the two classes of homeothermic
                      vertebrates) not only coincide with quantum-transition
                      reference temperatures but are also related to pronounced
                      transitions in hemoglobin oxygen saturation. This suggests
                      that the evolution of body temperatures in different
                      homeothermic species might involve an interplay between
                      critical parameters of oxygen supply on the one hand and
                      quantum-physical rotational transition temperatures of water
                      on the other. Casting the IWQ-model concept into a concise
                      formula: Proteins sense and water sets critical
                      physiological temperatures.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1152/ajpregu.00236.2024},
      url          = {https://juser.fz-juelich.de/record/1043688},
}