Home > Publications database > The molecular origin of body temperature in homeothermic species > print

001     1043688
005     20251113202117.0
024 7 _ |a 10.1152/ajpregu.00236.2024
|2 doi
024 7 _ |a 0363-6119
|2 ISSN
024 7 _ |a 1522-1490
|2 ISSN
024 7 _ |a 10.34734/FZJ-2025-02986
|2 datacite_doi
037 _ _ |a FZJ-2025-02986
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Artmann, Gerhard M.
|0 0000-0003-2874-6632
|b 0
|e Corresponding author
245 _ _ |a The molecular origin of body temperature in homeothermic species
260 _ _ |a Bethesda, Md.
|c 2025
|b American Physiological Society
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1763039385_26406
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a We propose the Interfacial Water Quantum-transition model (IWQ model) as a novel paradigm explaining temperature-dependent structural and functional transitions (discontinuities) observed in proteins. The central postulate states that experimentally measured critical temperatures, TC, are related to physical reference temperatures, TW, defined by rotational quantum transitions of temporarily free water molecules in the protein-water interface. Applicability of this concept is demonstrated using transitions observed in two disparate model systems, viz., hemoglobin and thermosensitive TRP channels. We propose that the same mechanism underlies the definition of basal body temperatures in homeotherms, the reference temperature for humans being TW=36.32°C. Specifically, we demonstrate that the body temperatures of both human and chicken (representing the two classes of homeothermic vertebrates) not only coincide with quantum-transition reference temperatures but are also related to pronounced transitions in hemoglobin oxygen saturation. This suggests that the evolution of body temperatures in different homeothermic species might involve an interplay between critical parameters of oxygen supply on the one hand and quantum-physical rotational transition temperatures of water on the other. Casting the IWQ-model concept into a concise formula: Proteins sense and water sets critical physiological temperatures.
536 _ _ |a 5241 - Molecular Information Processing in Cellular Systems (POF4-524)
|0 G:(DE-HGF)POF4-5241
|c POF4-524
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de
700 1 _ |a Weiergräber, Oliver H.
|0 P:(DE-Juel1)131988
|b 1
700 1 _ |a Damiati, Samar
|0 0000-0002-6747-0408
|b 2
700 1 _ |a Firat, Ipek Seda
|0 0000-0001-5073-3315
|b 3
700 1 _ |a Artmann, Aysegül Temiz
|0 P:(DE-HGF)0
|b 4
|e Corresponding author
773 _ _ |a 10.1152/ajpregu.00236.2024
|g p. ajpregu.00236.2024
|0 PERI:(DE-600)1477297-8
|n 4
|p R509-R597
|t American journal of physiology / Regulatory, integrative and comparative physiology
|v 329
|y 2025
|x 0363-6119
856 4 _ |u https://juser.fz-juelich.de/record/1043688/files/artmann-et-al-2025-the-molecular-origin-of-body-temperature-in-homeothermic-species.pdf
|y OpenAccess
909 C O |o oai:juser.fz-juelich.de:1043688
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)131988
913 1 _ |a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|1 G:(DE-HGF)POF4-520
|0 G:(DE-HGF)POF4-524
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Molecular and Cellular Information Processing
|9 G:(DE-HGF)POF4-5241
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2025-01-06
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b AM J PHYSIOL-REG I : 2022
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2025-01-06
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2025-01-06
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2025-01-06
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2025-01-06
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2025-01-06
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2025-01-06
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)IBI-7-20200312
|k IBI-7
|l Strukturbiochemie
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)IBI-7-20200312
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21