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@ARTICLE{Federmann:1043713,
      author       = {Federmann, Lydia M. and Sindermann, Lisa and Primus,
                      Sabrina and Raimondo, Federico and Oexle, Konrad and
                      Goltermann, Janik and Winkelmann, Juliane and Nöthen,
                      Markus M. and Amunts, Katrin and Mühleisen, Thomas W. and
                      Cichon, Sven and Eickhoff, Simon B. and Hoffstaedter, Felix
                      and Dannlowski, Udo and Patil, Kaustubh R. and Forstner,
                      Andreas J.},
      title        = {{N}eurobiological correlates of schizophrenia-specific and
                      highly pleiotropic genetic risk scores for neuropsychiatric
                      disorders},
      journal      = {Translational Psychiatry},
      volume       = {15},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2025-02999},
      pages        = {230},
      year         = {2025},
      abstract     = {Neuropsychiatric disorders show shared and distinct
                      neurobiological correlates. A cross-disorder genome-wide
                      association study (GWAS) identified 23 highly pleiotropic
                      single-nucleotide polymorphisms (SNPs) that were associated
                      with at least four neuropsychiatric disorders, and 22 SNPs
                      that were associated predominantly with schizophrenia.
                      Exploring their link to brain-related traits might advance
                      understanding their distinct neurobiological processes.
                      Using the UK Biobank data (n = 28,952), this study examined
                      the association of both a genetic risk score (GRS) for
                      highly pleiotropic SNPs (PleioPsych-GRS), and a GRS for
                      predominantly schizophrenia-associated SNPs (SCZ-GRS) with
                      154 measures of subcortical volume, cortical thickness, and
                      surface area as well as 12 outcomes related to mental
                      health. To generate further insights at the individual SNP
                      level, the association between SNPs and brain structure was
                      examined using GWAS summary statistics. The PleioPsych-GRS
                      showed no significant association with brain structure after
                      correction for multiple testing. The SCZ-GRS showed a
                      significant association with an increased surface area of
                      the lateral orbitofrontal region, and an increased volume of
                      the putamen, among others. The PleioPsych-GRS and the
                      SCZ-GRS were associated with eight and four outcomes related
                      to mental health, respectively. Two highly pleiotropic and
                      10 SCZ-associated SNPs were associated with several
                      structural brain phenotypes. Taken together, these findings
                      indicated that GRSs of highly pleiotropic SNPs and
                      predominantly schizophrenia-associated SNPs have partly
                      distinct associations with brain structure and outcomes
                      related to mental health. Thus, investigating
                      schizophrenia-specific and pleiotropic variants may improve
                      our understanding of the neurobiology of neuropsychiatric
                      disorders.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40617812},
      UT           = {WOS:001522801400003},
      doi          = {10.1038/s41398-025-03440-1},
      url          = {https://juser.fz-juelich.de/record/1043713},
}