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@MISC{Kuckertz:1043717,
      author       = {Kuckertz, Anika and Palomero-Gallagher, Nicola and Funck,
                      Thomas},
      title        = {{A}tlas of muscarinic {M}2 receptor distributions in the
                      rat brain (v2)},
      publisher    = {EBRAINS},
      reportid     = {FZJ-2025-03003},
      year         = {2025},
      abstract     = {Recent technological and methodological advances have
                      facilitated the implementation and standardization of
                      functional magnetic resonance imaging (fMRI) studies in
                      rodents. Integration of such fMRI data with maps coding for
                      the cyto- and receptor architectonic organization of the
                      brain, as well as of its structural connectivity patterns,
                      will facilitate the advance of our understanding of the
                      biological underpinnings of functional networks and
                      accelerate translational research using rat models. This
                      dataset provides a high-resolution three-dimensional (3D)
                      reconstruction of receptor autoradiographs coding for the
                      distribution of the cholinergic muscarinic M2 receptor
                      throughout the entire rat brain. The autoradiographs were
                      obtained by means of in vitro receptor autoradiography using
                      the specific agonist [3H]oxotremorine-M and digitization of
                      the ensuing autoradiographs to enable their densitometric
                      analysis. The pipeline BrainBuilder, developed for the 3D
                      reconstruction of 2D multimodal histological datasets, was
                      used for the reconstruction. The resulting 3D volume was
                      registered to the Waxholm Space rat brain atlas (version 4),
                      thus enabling its integration with fMRI data.},
      keywords     = {Neuroscience (Other)},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5254 - Neuroscientific Data Analytics and AI (POF4-525) /
                      HBP SGA3 - Human Brain Project Specific Grant Agreement 3
                      (945539) / HIBALL - Helmholtz International BigBrain
                      Analytics and Learning Laboratory (HIBALL) (InterLabs-0015)
                      / EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to
                      Advance Neuroscience and Brain Health (101147319)},
      pid          = {G:(DE-HGF)POF4-5254 / G:(EU-Grant)945539 /
                      G:(DE-HGF)InterLabs-0015 / G:(EU-Grant)101147319},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.25493/GF7X-2AU},
      url          = {https://juser.fz-juelich.de/record/1043717},
}