%0 Journal Article
%A Olubiyi, Olujide Oludayo
%A Attah, Francis Alfred
%A Strodel, Birgit
%A Eberle, Raphael Josef
%A Coronado, Monika Aparecida
%A Akinseinde, Oluwadotun
%A Onyeaghala, Augustine Anayochukwu
%A Uzochukwu, Ikemefuna Chijioke
%A Kotila, Olayinka Adejoke
%A Dada-Adegbola, Hannah
%A Adepiti, Awodayo Oluwatoyin
%A Elujoba, Anthony Adebolu
%A Babalola, Chinedum Peace
%T Novel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities
%J Food chemistry advances
%V 7
%@ 2772-753X
%C [Amsterdam]
%I Elsevier
%M FZJ-2025-03009
%P 100969 -
%D 2025
%X The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). In this work, the therapeutic potentials of four new polyherbal dietary preparations – VIVE (five plants), FORTE1(fortified VIVE), COMBI-5 (five spices) and MOK (Moringa seed) as well as four individual ethnomedicinal plants were investigated. Computational screening revealed chemical structures capable of establishing moderate to strong interaction with SARS-CoV-2′s main protease enzyme, while in vitro screening against the viral protease clearly established inhibitory potencies. The individual plant extracts making up VIVE and FORTE1 showed mild (494.9 ± 19.6 µg/ml) to moderate (21.5 ± 1.1 µg/ml) inhibitory activity against the viral enzyme in vitro; highest activity was obtained in the polyherbal VIVE preparation (17.3 ± 1.4 µg/ml). The MOK exerted total inhibition – 100 % (IC50 -3.6 ± 0.9) of the viral enzyme while COMBI-5 produced an inhibition of 95 %(IC50 - 0.9 ± 0.1). These results revealed the potential of specialized metabolites within these widely consumed dietary herbal products for the management of COVID-19 and related viral threats.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1016/j.focha.2025.100969
%U https://juser.fz-juelich.de/record/1043723