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001043723 1001_ $$0P:(DE-Juel1)138971$$aOlubiyi, Olujide Oludayo$$b0$$eCorresponding author
001043723 245__ $$aNovel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities
001043723 260__ $$a[Amsterdam]$$bElsevier$$c2025
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001043723 520__ $$aThe outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). In this work, the therapeutic potentials of four new polyherbal dietary preparations – VIVE (five plants), FORTE1(fortified VIVE), COMBI-5 (five spices) and MOK (Moringa seed) as well as four individual ethnomedicinal plants were investigated. Computational screening revealed chemical structures capable of establishing moderate to strong interaction with SARS-CoV-2′s main protease enzyme, while in vitro screening against the viral protease clearly established inhibitory potencies. The individual plant extracts making up VIVE and FORTE1 showed mild (494.9 ± 19.6 µg/ml) to moderate (21.5 ± 1.1 µg/ml) inhibitory activity against the viral enzyme in vitro; highest activity was obtained in the polyherbal VIVE preparation (17.3 ± 1.4 µg/ml). The MOK exerted total inhibition – 100 % (IC50 -3.6 ± 0.9) of the viral enzyme while COMBI-5 produced an inhibition of 95 %(IC50 - 0.9 ± 0.1). These results revealed the potential of specialized metabolites within these widely consumed dietary herbal products for the management of COVID-19 and related viral threats.
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001043723 7001_ $$00000-0003-0787-0204$$aAttah, Francis Alfred$$b1
001043723 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b2$$ufzj
001043723 7001_ $$0P:(DE-Juel1)179561$$aEberle, Raphael Josef$$b3
001043723 7001_ $$aCoronado, Monika Aparecida$$b4
001043723 7001_ $$0P:(DE-HGF)0$$aAkinseinde, Oluwadotun$$b5
001043723 7001_ $$0P:(DE-HGF)0$$aOnyeaghala, Augustine Anayochukwu$$b6
001043723 7001_ $$0P:(DE-HGF)0$$aUzochukwu, Ikemefuna Chijioke$$b7
001043723 7001_ $$0P:(DE-HGF)0$$aKotila, Olayinka Adejoke$$b8
001043723 7001_ $$0P:(DE-HGF)0$$aDada-Adegbola, Hannah$$b9
001043723 7001_ $$0P:(DE-HGF)0$$aAdepiti, Awodayo Oluwatoyin$$b10
001043723 7001_ $$0P:(DE-HGF)0$$aElujoba, Anthony Adebolu$$b11
001043723 7001_ $$0P:(DE-HGF)0$$aBabalola, Chinedum Peace$$b12$$eCorresponding author
001043723 773__ $$0PERI:(DE-600)3116248-4$$a10.1016/j.focha.2025.100969$$gVol. 7, p. 100969 -$$p100969 -$$tFood chemistry advances$$v7$$x2772-753X$$y2025
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