TY  - JOUR
AU  - Olubiyi, Olujide Oludayo
AU  - Attah, Francis Alfred
AU  - Strodel, Birgit
AU  - Eberle, Raphael Josef
AU  - Coronado, Monika Aparecida
AU  - Akinseinde, Oluwadotun
AU  - Onyeaghala, Augustine Anayochukwu
AU  - Uzochukwu, Ikemefuna Chijioke
AU  - Kotila, Olayinka Adejoke
AU  - Dada-Adegbola, Hannah
AU  - Adepiti, Awodayo Oluwatoyin
AU  - Elujoba, Anthony Adebolu
AU  - Babalola, Chinedum Peace
TI  - Novel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities
JO  - Food chemistry advances
VL  - 7
SN  - 2772-753X
CY  - [Amsterdam]
PB  - Elsevier
M1  - FZJ-2025-03009
SP  - 100969 -
PY  - 2025
AB  - The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). In this work, the therapeutic potentials of four new polyherbal dietary preparations – VIVE (five plants), FORTE1(fortified VIVE), COMBI-5 (five spices) and MOK (Moringa seed) as well as four individual ethnomedicinal plants were investigated. Computational screening revealed chemical structures capable of establishing moderate to strong interaction with SARS-CoV-2′s main protease enzyme, while in vitro screening against the viral protease clearly established inhibitory potencies. The individual plant extracts making up VIVE and FORTE1 showed mild (494.9 ± 19.6 µg/ml) to moderate (21.5 ± 1.1 µg/ml) inhibitory activity against the viral enzyme in vitro; highest activity was obtained in the polyherbal VIVE preparation (17.3 ± 1.4 µg/ml). The MOK exerted total inhibition – 100 % (IC50 -3.6 ± 0.9) of the viral enzyme while COMBI-5 produced an inhibition of 95 %(IC50 - 0.9 ± 0.1). These results revealed the potential of specialized metabolites within these widely consumed dietary herbal products for the management of COVID-19 and related viral threats.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.focha.2025.100969
UR  - https://juser.fz-juelich.de/record/1043723
ER  -