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@ARTICLE{Olubiyi:1043723,
      author       = {Olubiyi, Olujide Oludayo and Attah, Francis Alfred and
                      Strodel, Birgit and Eberle, Raphael Josef and Coronado,
                      Monika Aparecida and Akinseinde, Oluwadotun and Onyeaghala,
                      Augustine Anayochukwu and Uzochukwu, Ikemefuna Chijioke and
                      Kotila, Olayinka Adejoke and Dada-Adegbola, Hannah and
                      Adepiti, Awodayo Oluwatoyin and Elujoba, Anthony Adebolu and
                      Babalola, Chinedum Peace},
      title        = {{N}ovel dietary herbal preparations with inhibitory
                      activities against multiple {SARS}-{C}o{V}-2 targets: {A}
                      multidisciplinary investigation into antiviral activities},
      journal      = {Food chemistry advances},
      volume       = {7},
      issn         = {2772-753X},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2025-03009},
      pages        = {100969 -},
      year         = {2025},
      abstract     = {The outbreak of the COVID-19 pandemic has resulted in not
                      <7.1million deaths globally as of December 2024. Many new
                      variants of concern have continued to emerge since the
                      initial outbreak of the original SARS-CoV-2 virus traceable
                      to the Wuhan strain (Wuhan-Hu-1). In this work, the
                      therapeutic potentials of four new polyherbal dietary
                      preparations – VIVE (five plants), FORTE1(fortified VIVE),
                      COMBI-5 (five spices) and MOK (Moringa seed) as well as four
                      individual ethnomedicinal plants were investigated.
                      Computational screening revealed chemical structures capable
                      of establishing moderate to strong interaction with
                      SARS-CoV-2′s main protease enzyme, while in vitro
                      screening against the viral protease clearly established
                      inhibitory potencies. The individual plant extracts making
                      up VIVE and FORTE1 showed mild (494.9 ± 19.6 µg/ml) to
                      moderate (21.5 ± 1.1 µg/ml) inhibitory activity against
                      the viral enzyme in vitro; highest activity was obtained in
                      the polyherbal VIVE preparation (17.3 ± 1.4 µg/ml). The
                      MOK exerted total inhibition – 100 $\%$ (IC50 -3.6 ± 0.9)
                      of the viral enzyme while COMBI-5 produced an inhibition of
                      95 $\%(IC50$ - 0.9 ± 0.1). These results revealed the
                      potential of specialized metabolites within these widely
                      consumed dietary herbal products for the management of
                      COVID-19 and related viral threats.},
      cin          = {IBI-7},
      ddc          = {660},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.focha.2025.100969},
      url          = {https://juser.fz-juelich.de/record/1043723},
}