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| Home > Publications database > Novel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities > print |
| 001 | 1043723 | ||
| 005 | 20250717202252.0 | ||
| 024 | 7 | _ | |a 10.1016/j.focha.2025.100969 |2 doi |
| 024 | 7 | _ | |a 10.34734/FZJ-2025-03009 |2 datacite_doi |
| 037 | _ | _ | |a FZJ-2025-03009 |
| 082 | _ | _ | |a 660 |
| 100 | 1 | _ | |a Olubiyi, Olujide Oludayo |0 P:(DE-Juel1)138971 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Novel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities |
| 260 | _ | _ | |a [Amsterdam] |c 2025 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1752742609_3508 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). In this work, the therapeutic potentials of four new polyherbal dietary preparations – VIVE (five plants), FORTE1(fortified VIVE), COMBI-5 (five spices) and MOK (Moringa seed) as well as four individual ethnomedicinal plants were investigated. Computational screening revealed chemical structures capable of establishing moderate to strong interaction with SARS-CoV-2′s main protease enzyme, while in vitro screening against the viral protease clearly established inhibitory potencies. The individual plant extracts making up VIVE and FORTE1 showed mild (494.9 ± 19.6 µg/ml) to moderate (21.5 ± 1.1 µg/ml) inhibitory activity against the viral enzyme in vitro; highest activity was obtained in the polyherbal VIVE preparation (17.3 ± 1.4 µg/ml). The MOK exerted total inhibition – 100 % (IC50 -3.6 ± 0.9) of the viral enzyme while COMBI-5 produced an inhibition of 95 %(IC50 - 0.9 ± 0.1). These results revealed the potential of specialized metabolites within these widely consumed dietary herbal products for the management of COVID-19 and related viral threats. |
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| 700 | 1 | _ | |a Attah, Francis Alfred |0 0000-0003-0787-0204 |b 1 |
| 700 | 1 | _ | |a Strodel, Birgit |0 P:(DE-Juel1)132024 |b 2 |u fzj |
| 700 | 1 | _ | |a Eberle, Raphael Josef |0 P:(DE-Juel1)179561 |b 3 |
| 700 | 1 | _ | |a Coronado, Monika Aparecida |b 4 |
| 700 | 1 | _ | |a Akinseinde, Oluwadotun |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Onyeaghala, Augustine Anayochukwu |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Uzochukwu, Ikemefuna Chijioke |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Kotila, Olayinka Adejoke |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Dada-Adegbola, Hannah |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Adepiti, Awodayo Oluwatoyin |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Elujoba, Anthony Adebolu |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Babalola, Chinedum Peace |0 P:(DE-HGF)0 |b 12 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.focha.2025.100969 |g Vol. 7, p. 100969 - |0 PERI:(DE-600)3116248-4 |p 100969 - |t Food chemistry advances |v 7 |y 2025 |x 2772-753X |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1043723/files/1-s2.0-S2772753X25000851-main.pdf |y OpenAccess |
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