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@MISC{Primus:1044260,
      author       = {Primus, Sabrina Alexandra and Hoffstaedter, Felix and
                      Raimondo, Federico and Eickhoff, Simon and Winkelmann,
                      Juliane and Oexle, Konrad and Patil, Kaustubh},
      title        = {{S}upplementary data to the article "{B}eyond {V}olume:
                      {U}nraveling the {G}enetics of {H}uman {B}rain {G}eometry"},
      reportid     = {FZJ-2025-03130},
      year         = {2025},
      abstract     = {Brain geometry impacts brain function. A quantitative
                      encoding of form is provided by the Laplace-Beltrami
                      operator’s spectrum of eigenvalues (LBS). We examined LBS
                      genetics of 22 subcortical brain structures and cerebellum
                      in 19,862 healthy White-British UK Biobank participants by
                      multivariate GWAS on the first 49 eigenvalues each.
                      Controlling for surface and volume, we identified 80 unique
                      variants influencing the shapes of one or several
                      structures, with the highest yield (37 variants) for brain
                      stem. The previously known influence of several of these
                      loci on basic morphology, such as volume, is thus shown to
                      also influence complex shape. Known associations of observed
                      loci with blood pressure, neurodegeneration, alcohol
                      consumption, and mental disorders hint at preclinical stages
                      of these conditions potentially mediating the genetic effect
                      on brain morphology. Significant correlations between LBS of
                      several brain structures and the polygenic risks of
                      hypertension, ischemic stroke and schizophrenia evince brain
                      shapes as early biomarkers.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://juser.fz-juelich.de/record/1044260},
}