001044277 001__ 1044277
001044277 005__ 20250804115216.0
001044277 0247_ $$2doi$$a10.1055/a-2547-3678
001044277 0247_ $$2ISSN$$a1864-4538
001044277 0247_ $$2ISSN$$a1864-175X
001044277 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-03147
001044277 0247_ $$2WOS$$aWOS:001500970300015
001044277 037__ $$aFZJ-2025-03147
001044277 082__ $$a910
001044277 1001_ $$0P:(DE-Juel1)191151$$aMichno, Manuel$$b0$$eCorresponding author
001044277 245__ $$aSauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren
001044277 260__ $$aStuttgart$$bThieme$$c2025
001044277 3367_ $$2DRIVER$$aarticle
001044277 3367_ $$2DataCite$$aOutput Types/Journal article
001044277 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1753341052_32739
001044277 3367_ $$2BibTeX$$aARTICLE
001044277 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001044277 3367_ $$00$$2EndNote$$aJournal Article
001044277 520__ $$aIn animal studies, it has been observed that the neuromodula-tor adenosine is released into the interstitial space of the brainduring hypoxia and protects the brain from oxygen deficiencyand overexertion by adjusting cerebral blood flow, metabolismand electrical activity. This study exposed 10 subjects to aninterval of 30-min hypoxia equivalent to the partial pressure ofoxygen at about 5500 m. This resulted in a significant reductionin A 1 adenosine receptor (A 1 AR) availability in the human brain,a significant increase in heart rate, and a significant slowing ofreaction speed. This is to our knowledge the first demonstra-tion in humans that acute hypoxia reduces A 1 AR availability inthe brain. This result supports the hypothesis that hypoxia-in-duced adenosine release leads to increased occupancy of theA 1 AR and can thus pave the way for future countermeasures.
001044277 536__ $$0G:(DE-HGF)POF4-5253$$a5253 - Neuroimaging (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001044277 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001044277 7001_ $$0P:(DE-HGF)0$$aSchmitz, Jan$$b1
001044277 7001_ $$0P:(DE-Juel1)179271$$aFoerges, Anna L.$$b2
001044277 7001_ $$0P:(DE-Juel1)133864$$aBeer, Simone$$b3
001044277 7001_ $$0P:(DE-HGF)0$$aJordan, Jens$$b4
001044277 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b5
001044277 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b6
001044277 7001_ $$0P:(DE-HGF)0$$aAeschbach, Daniel$$b7
001044277 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b8
001044277 7001_ $$0P:(DE-HGF)0$$aTank, Jens$$b9
001044277 7001_ $$0P:(DE-HGF)0$$aWeis, Henning$$b10
001044277 7001_ $$0P:(DE-HGF)0$$aElmenhorst, Eva-Maria$$b11
001044277 7001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b12
001044277 773__ $$0PERI:(DE-600)2399335-2$$a10.1055/a-2547-3678$$gVol. 32, no. 03, p. 146 - 154$$n03$$p146 - 154$$tFlugmedizin, Tropenmedizin, Reisemedizin$$v32$$x1864-4538$$y2025
001044277 8564_ $$uhttps://juser.fz-juelich.de/record/1044277/files/le25071700092.pdf$$yRestricted
001044277 8564_ $$uhttps://juser.fz-juelich.de/record/1044277/files/le25071700092a.pdf$$yOpenAccess$$zStatID:(DE-HGF)0510
001044277 909CO $$ooai:juser.fz-juelich.de:1044277$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)191151$$aForschungszentrum Jülich$$b0$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)179271$$aForschungszentrum Jülich$$b2$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)133864$$aForschungszentrum Jülich$$b3$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166419$$aForschungszentrum Jülich$$b5$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177611$$aForschungszentrum Jülich$$b6$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131672$$aForschungszentrum Jülich$$b8$$kFZJ
001044277 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131679$$aForschungszentrum Jülich$$b12$$kFZJ
001044277 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5253$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001044277 9141_ $$y2025
001044277 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-05
001044277 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFLUGMEDIZIN TROPENME : 2022$$d2024-12-05
001044277 915__ $$0StatID:(DE-HGF)0112$$2StatID$$aWoS$$bEmerging Sources Citation Index$$d2024-12-05
001044277 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001044277 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-05
001044277 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-05
001044277 920__ $$lyes
001044277 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x0
001044277 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x1
001044277 980__ $$ajournal
001044277 980__ $$aVDB
001044277 980__ $$aUNRESTRICTED
001044277 980__ $$aI:(DE-Juel1)INM-5-20090406
001044277 980__ $$aI:(DE-Juel1)INM-2-20090406
001044277 9801_ $$aFullTexts