TY  - JOUR
AU  - Michno, Manuel
AU  - Schmitz, Jan
AU  - Foerges, Anna L.
AU  - Beer, Simone
AU  - Jordan, Jens
AU  - Neumaier, Bernd
AU  - Drzezga, Alexander
AU  - Aeschbach, Daniel
AU  - Bauer, Andreas
AU  - Tank, Jens
AU  - Weis, Henning
AU  - Elmenhorst, Eva-Maria
AU  - Elmenhorst, David
TI  - Sauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren
JO  - Flugmedizin, Tropenmedizin, Reisemedizin
VL  - 32
IS  - 03
SN  - 1864-4538
CY  - Stuttgart
PB  - Thieme
M1  - FZJ-2025-03147
SP  - 146 - 154
PY  - 2025
AB  - In animal studies, it has been observed that the neuromodula-tor adenosine is released into the interstitial space of the brainduring hypoxia and protects the brain from oxygen deficiencyand overexertion by adjusting cerebral blood flow, metabolismand electrical activity. This study exposed 10 subjects to aninterval of 30-min hypoxia equivalent to the partial pressure ofoxygen at about 5500 m. This resulted in a significant reductionin A 1 adenosine receptor (A 1 AR) availability in the human brain,a significant increase in heart rate, and a significant slowing ofreaction speed. This is to our knowledge the first demonstra-tion in humans that acute hypoxia reduces A 1 AR availability inthe brain. This result supports the hypothesis that hypoxia-in-duced adenosine release leads to increased occupancy of theA 1 AR and can thus pave the way for future countermeasures.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:001500970300015
DO  - DOI:10.1055/a-2547-3678
UR  - https://juser.fz-juelich.de/record/1044277
ER  -