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@ARTICLE{Michno:1044277,
      author       = {Michno, Manuel and Schmitz, Jan and Foerges, Anna L. and
                      Beer, Simone and Jordan, Jens and Neumaier, Bernd and
                      Drzezga, Alexander and Aeschbach, Daniel and Bauer, Andreas
                      and Tank, Jens and Weis, Henning and Elmenhorst, Eva-Maria
                      and Elmenhorst, David},
      title        = {{S}auerstoffmangel im {G}ehirn: {P}erfusion und
                      {V}erfügbarkeit von {A}1-{A}denosinrezeptoren},
      journal      = {Flugmedizin, Tropenmedizin, Reisemedizin},
      volume       = {32},
      number       = {03},
      issn         = {1864-4538},
      address      = {Stuttgart},
      publisher    = {Thieme},
      reportid     = {FZJ-2025-03147},
      pages        = {146 - 154},
      year         = {2025},
      abstract     = {In animal studies, it has been observed that the
                      neuromodula-tor adenosine is released into the interstitial
                      space of the brainduring hypoxia and protects the brain from
                      oxygen deficiencyand overexertion by adjusting cerebral
                      blood flow, metabolismand electrical activity. This study
                      exposed 10 subjects to aninterval of 30-min hypoxia
                      equivalent to the partial pressure ofoxygen at about 5500 m.
                      This resulted in a significant reductionin A 1 adenosine
                      receptor (A 1 AR) availability in the human brain,a
                      significant increase in heart rate, and a significant
                      slowing ofreaction speed. This is to our knowledge the first
                      demonstra-tion in humans that acute hypoxia reduces A 1 AR
                      availability inthe brain. This result supports the
                      hypothesis that hypoxia-in-duced adenosine release leads to
                      increased occupancy of theA 1 AR and can thus pave the way
                      for future countermeasures.},
      cin          = {INM-5 / INM-2},
      ddc          = {910},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:001500970300015},
      doi          = {10.1055/a-2547-3678},
      url          = {https://juser.fz-juelich.de/record/1044277},
}