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@ARTICLE{Schaffrath:1044407,
      author       = {Schaffrath, Kim and Ingensiep, Claudia and Müller, Frank
                      and Walter, Peter and Johnen, Sandra},
      title        = {{E}ffects of taurine, brimonidine and betaxolol on
                      oscillation modulation and stimulation efficiency in
                      degenerated rd10 mouse retinas},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-03170},
      pages        = {20209},
      year         = {2025},
      note         = {The authors thank the Institute of Laboratory Animal
                      Science (Faculty of Medicine, RWTH Aachen University) for
                      support, Anne Rohn (Department of Ophthalmology, University
                      Hospital RWTH Aachen) for excellent technical assistance,
                      and Sabine Diarra for her efforts to prepare the grant
                      application for the Pro Retina Foundation.Open Access
                      funding enabled and organized by Projekt DEAL.},
      abstract     = {The rd10 mouse is a widely used model for degenerative
                      retinal diseases such as retinitis pigmentosa(RP). Its
                      retina shows rhythmic spontaneous activity at a frequency of
                      three to seven Hz, andthe retinal ganglion cells (RGCs) are
                      less electrically excitable. We hypothesize that the
                      electricalexcitability can be improved by suppressing the
                      oscillations using the neuroprotective
                      drugs2-aminoethanesulphonic acid (taurine), brimonidine and
                      betaxolol. These are involved in calciumhomeostasis and may
                      play a crucial role in neuroprotection and excitotoxicity by
                      preventing Ca2+overload. Spontaneous activity and responses
                      to electrical stimulation of isolated retinas from3- to
                      4-month-old rd10 mice were recorded using multielectrode
                      arrays. At defined times, theneuroprotectants were
                      repeatedly added to the medium according to a standardized
                      protocol toanalyze the reproducibility and reversibility of
                      their effects. Taurine and betaxolol significantly
                      reducedoscillations and bursting behavior and ameliorated
                      electrical efficiency. Brimonidine only reduced thefrequency
                      of oscillations. The effects on oscillation, spontaneous
                      firing frequency, bursting behaviorand stimulation
                      efficiency were reproducible and reversible. The drugs
                      tested appear to be promisingtherapeutic candidates for
                      improving the residual function of RGCs. They will be
                      further investigatedand combined with other RP treatments,
                      such as retinal prostheses, in the future.},
      cin          = {IBI-1 / INW-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-1-20200312 / I:(DE-Juel1)INW-1-20231219},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524) / GRK 2610 - GRK 2610: Innovative Schnittstellen
                      zur Retina für optimiertes künstliches Sehen -
                      InnoRetVision (424556709)},
      pid          = {G:(DE-HGF)POF4-5244 / G:(GEPRIS)424556709},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41598-025-06440-9},
      url          = {https://juser.fz-juelich.de/record/1044407},
}