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@ARTICLE{Jung:1044417,
      author       = {Jung, Marie and Wang, Jing and Montes, Viviana Rincón and
                      Offenhäusser, Andreas and Willuweit, Antje and Müller,
                      Frank},
      title        = {{L}ate emergence of pathological oscillatory activity in
                      the retina of the {R}etinitis pigmentosa model {RCS}
                      ({R}oyal {C}ollege of {S}urgeons) rat},
      journal      = {PLOS ONE},
      volume       = {20},
      number       = {5},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {FZJ-2025-03180},
      pages        = {e0324345 -},
      year         = {2025},
      note         = {This work was supported by the Deutsche
                      Forschungsgemeinschaft DFG under GRK 2610/01.},
      abstract     = {Retinitis pigmentosa (RP) is a leading cause of blindness.
                      The best studied modelsof human RP are the rd1 and rd10
                      mouse and the RCS rat (Royal College of Surgeons).In many
                      models after degeneration of the photoreceptors, a
                      pathologicalrhythmic activity of the retina as well as
                      lowered efficiency of electrical stimulationwere observed.
                      In rd10 retina, both events were shown to be intimately
                      linked. Surprisingly,to our knowledge no retinal
                      oscillations have been reported in RCS retina.As
                      oscillations might interfere with the performance of
                      therapeutic approaches torestore vision, e.g., retinal
                      prostheses, it is important to know, whether they are
                      acommon feature of retinal degeneration. Electrical activity
                      was recorded in retinaeof 3–19 months (M3-19) old RCS rats
                      in vitro using planar and penetrating multielectrode-arrays.
                      Short deflections in the local field potential resembling
                      thoseobserved in oscillations in rd1 and rd10 retinae were
                      only sporadically found inM3 RCS retinae. Oscillations at
                      appr. 2 Hz occurred more often and were morepronounced the
                      older the animals were. Yet, even at M18-19 oscillatory
                      periodswere short and separated by long periods of
                      non-oscillatory activity. In summary, inadvanced stages of
                      degeneration, RCS retinae display oscillations similar to
                      rd1 andrd10 retinae. However, in RCS retina oscillatory
                      periods are shorter than in mousemodels and may, therefore,
                      have escaped detection in earlier studies. These
                      resultstogether with results observed in non-rodent models
                      suggest that pathological rhythmicactivity is a common
                      feature in RP models.},
      cin          = {IBI-1 / IBI-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-1-20200312 / I:(DE-Juel1)IBI-3-20200312 /
                      I:(DE-Juel1)INM-4-20090406},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524) / 5244 - Information Processing in Neuronal
                      Networks (POF4-524) / GRK 2610 - GRK 2610: Innovative
                      Schnittstellen zur Retina für optimiertes künstliches
                      Sehen - InnoRetVision (424556709)},
      pid          = {G:(DE-HGF)POF4-5243 / G:(DE-HGF)POF4-5244 /
                      G:(GEPRIS)424556709},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40424459},
      UT           = {WOS:001497877100037},
      doi          = {10.1371/journal.pone.0324345},
      url          = {https://juser.fz-juelich.de/record/1044417},
}