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| 001 | 1044417 | ||
| 005 | 20250901202249.0 | ||
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| 100 | 1 | _ | |a Jung, Marie |0 P:(DE-Juel1)188118 |b 0 |u fzj |
| 245 | _ | _ | |a Late emergence of pathological oscillatory activity in the retina of the Retinitis pigmentosa model RCS (Royal College of Surgeons) rat |
| 260 | _ | _ | |a San Francisco, California, US |c 2025 |b PLOS |
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| 500 | _ | _ | |a This work was supported by the Deutsche Forschungsgemeinschaft DFG under GRK 2610/01. |
| 520 | _ | _ | |a Retinitis pigmentosa (RP) is a leading cause of blindness. The best studied modelsof human RP are the rd1 and rd10 mouse and the RCS rat (Royal College of Surgeons).In many models after degeneration of the photoreceptors, a pathologicalrhythmic activity of the retina as well as lowered efficiency of electrical stimulationwere observed. In rd10 retina, both events were shown to be intimately linked. Surprisingly,to our knowledge no retinal oscillations have been reported in RCS retina.As oscillations might interfere with the performance of therapeutic approaches torestore vision, e.g., retinal prostheses, it is important to know, whether they are acommon feature of retinal degeneration. Electrical activity was recorded in retinaeof 3–19 months (M3-19) old RCS rats in vitro using planar and penetrating multielectrode-arrays. Short deflections in the local field potential resembling thoseobserved in oscillations in rd1 and rd10 retinae were only sporadically found inM3 RCS retinae. Oscillations at appr. 2 Hz occurred more often and were morepronounced the older the animals were. Yet, even at M18-19 oscillatory periodswere short and separated by long periods of non-oscillatory activity. In summary, inadvanced stages of degeneration, RCS retinae display oscillations similar to rd1 andrd10 retinae. However, in RCS retina oscillatory periods are shorter than in mousemodels and may, therefore, have escaped detection in earlier studies. These resultstogether with results observed in non-rodent models suggest that pathological rhythmicactivity is a common feature in RP models. |
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| 536 | _ | _ | |a GRK 2610 - GRK 2610: Innovative Schnittstellen zur Retina für optimiertes künstliches Sehen - InnoRetVision (424556709) |0 G:(GEPRIS)424556709 |c 424556709 |x 2 |
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| 700 | 1 | _ | |a Müller, Frank |0 P:(DE-Juel1)131939 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1371/journal.pone.0324345 |g Vol. 20, no. 5, p. e0324345 - |0 PERI:(DE-600)2267670-3 |n 5 |p e0324345 - |t PLOS ONE |v 20 |y 2025 |x 1932-6203 |
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