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@ARTICLE{Semmler:1044506,
      author       = {Semmler, Carolin and Wunderle, Veronika and Kuzu, Taylan D.
                      and Onur, Oezguer A. and Grefkes, Christian and Barbe,
                      Michael T. and Fink, Gereon R. and Weiss-Blankenhorn, Peter},
      title        = {{I}nstrument-supported gait analysis characterizes gait
                      domain changes in patients with suspected normal pressure
                      hydrocephalus},
      journal      = {Neurological research and practice},
      volume       = {7},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2025-03243},
      pages        = {41},
      year         = {2025},
      note         = {Open Access funding enabled and organized by Projekt DEAL.
                      The Deutsche Forschungsgemeinschaft (DFG, German Research
                      Foundation)—Project-ID 431549029—SFB 1451 funded this
                      project. CG received additional funding from project GRK
                      2783. OO received consulting fees from Biogen and Lilly and
                      lecture fees from Eisai, Boston Scientific, and Functional
                      Neuromodulation. This work was also supported by a Marga and
                      Walter Boll-Foundation grant to OO and GRF.},
      abstract     = {AbstractBackground: Idiopathic Normal Pressure
                      Hydrocephalus (iNPH) is a potentially reversible cause of
                      cognitive impairment, urinary incontinence, and gait
                      disturbances, which typically present with a characteristic
                      slow, shuffling, and wide-based gait. Gait velocity, which
                      is reduced relative to healthy controls, improves in iNPH
                      patients following a spinal tap test. This study aimed at
                      evaluating the criterion of a $20\%$ gait velocity
                      improvement in the 10 m walk test to identify responders and
                      non-responders in a cohort of patients with probable iNPH
                      receiving a spinal tap test as well as the added value of
                      instrument-supported gait analysis.Methods: We assessed
                      pace, rhythm, variability, postural control, and force in 59
                      patients with clinically suspected iNPH undergoing a spinal
                      tap test, applying the 10 m walk test and an
                      instrument-supported gait analysis. The change in gait
                      velocity assessed in the 10 m walk test was used to
                      differentiate patients with a positive response to the
                      spinal tap (> $20\%$ improvement, responders) from those
                      with no relevant response (< $20\%$ improvement,
                      non-responders). Group differences were analyzed using
                      chi-square tests, independent sample t-tests, Mann-Whitney-U
                      tests and repeated measure ANOVAs.Results: Unlike
                      non-responders (n = 39), responders (n = 20) showed
                      significant changes in the gait domain pace in the 10 m walk
                      test. Moreover, instrument-supported gait analyses revealed
                      additional improvements in the gait domains variability,
                      rhythm, postural control and force in responders
                      only.Interpretation: This study confirmed the clinical
                      utility of the $20\%$ gait velocity improvement criterion
                      for differentiating responders and non-responders in a
                      cohort of patients with mostly probable iNPH, in whom
                      clinical parameters alone were insufficient for
                      classification. Notably, instrument-supported gait analysis
                      validated this criterion by providing a more comprehensive
                      characterization of gait disturbances compared to the 10 m
                      walk test. However, further-especially longitudinal-studies
                      are needed to reveal the full potential of the
                      instrument-supported gait analysis in patients with
                      (early/probable) iNPH.Keywords: Center of force; Center of
                      pressure; Ground reaction force; Kinetics; iNPH.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40524262},
      UT           = {WOS:001510002000001},
      doi          = {10.1186/s42466-025-00394-z},
      url          = {https://juser.fz-juelich.de/record/1044506},
}