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| Hauptseite > Publikationsdatenbank > Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize > print |
| Hauptseite > Publikationsdatenbank > Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize > print |
| 001 | 1044973 | ||
| 005 | 20250930132717.0 | ||
| 024 | 7 | _ | |a 10.1038/s41588-025-02246-7 |2 doi |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Engelhorn, Julia |0 0000-0002-6680-3012 |b 0 |
| 245 | _ | _ | |a Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize |
| 260 | _ | _ | |a London |c 2025 |b Macmillan Publishers Limited, part of Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Comprehensive maps of functional variation at transcription factor (TF) binding sites (cis-elements) are crucial for elucidating how genotype shapes phenotype. Here, we report the construction of a pan-cistrome of the maize leaf under well-watered and drought conditions. We quantified haplotype-specific TF footprints across a pan-genome of 25 maize hybrids and mapped over 200,000 variants, genetic, epigenetic, or both (termed binding quantitative trait loci (bQTL)), linked to cis-element occupancy. Three lines of evidence support the functional significance of bQTL: (1) coincidence with causative loci that regulate traits, including vgt1, ZmTRE1 and the MITE transposon near ZmNAC111 under drought; (2) bQTL allelic bias is shared between inbred parents and matches chromatin immunoprecipitation sequencing results; and (3) partitioning genetic variation across genomic regions demonstrates that bQTL capture the majority of heritable trait variation across ~72% of 143 phenotypes. Our study provides an auspicious approach to make functional cis-variation accessible at scale for genetic studies and targeted engineering of complex traits. |
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| 700 | 1 | _ | |a Snodgrass, Samantha J. |0 0000-0001-9209-6051 |b 1 |
| 700 | 1 | _ | |a Kok, Amelie |0 0009-0009-5930-5232 |b 2 |
| 700 | 1 | _ | |a Seetharam, Arun S. |0 0000-0002-6789-9298 |b 3 |
| 700 | 1 | _ | |a Schneider, Michael |0 P:(DE-Juel1)130948 |b 4 |u fzj |
| 700 | 1 | _ | |a Kiwit, Tatjana |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Singh, Ayush |0 0000-0003-0184-4486 |b 6 |
| 700 | 1 | _ | |a Banf, Michael |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Doan, Duong Thi Hai |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Khaipho-Burch, Merritt |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Runcie, Daniel E. |0 0000-0002-3008-9312 |b 10 |
| 700 | 1 | _ | |a Sánchez-Camargo, Victor A. |0 0000-0002-7184-0301 |b 11 |
| 700 | 1 | _ | |a Bader, Rechien |0 0009-0001-4738-190X |b 12 |
| 700 | 1 | _ | |a Vladimir Torres-Rodriguez, J. |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Sun, Guangchao |0 0000-0003-3942-6175 |b 14 |
| 700 | 1 | _ | |a Stam, Maike |0 0000-0003-0363-4677 |b 15 |
| 700 | 1 | _ | |a Fiorani, Fabio |0 P:(DE-Juel1)143649 |b 16 |
| 700 | 1 | _ | |a Beier, Sebastian |0 P:(DE-Juel1)191149 |b 17 |
| 700 | 1 | _ | |a Schnable, James C. |0 0000-0001-6739-5527 |b 18 |
| 700 | 1 | _ | |a Bass, Hank W. |0 0000-0003-0522-0881 |b 19 |
| 700 | 1 | _ | |a Hufford, Matthew B. |0 0000-0003-3945-1143 |b 20 |
| 700 | 1 | _ | |a Stich, Benjamin |0 0000-0001-6791-8068 |b 21 |
| 700 | 1 | _ | |a Frommer, Wolf B. |0 0000-0001-6465-0115 |b 22 |
| 700 | 1 | _ | |a Ross-Ibarra, Jeffrey |0 0000-0003-1656-4954 |b 23 |
| 700 | 1 | _ | |a Hartwig, Thomas |0 0000-0002-2707-2771 |b 24 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s41588-025-02246-7 |0 PERI:(DE-600)1494946-5 |p 2313–2322 |t Nature genetics |v 57 |y 2025 |x 1061-4036 |
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