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@ARTICLE{Till:1044990,
      author       = {Till, Katharina and Seinen, Anne-Bart and Wruck, Florian
                      and Sunderlikova, Vanda and Galmozzi, Carla V. and
                      Katranidis, Alexandros and Bukau, Bernd and Kramer, Günter
                      and Tans, Sander J.},
      title        = {{T}rigger factor accelerates nascent chain compaction and
                      folding},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {122},
      number       = {30},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2025-03475},
      pages        = {e2422678122},
      year         = {2025},
      abstract     = {Recent work indicates that many chaperones bind protein
                      chains already during their translation by ribosomes. While
                      chaperones are thought to merely “hold” the nascent
                      protein chains, current methods cannot study their
                      conformational changes. We simultaneously image single
                      chaperone binding and detect nascent protein conformation.
                      We show that the chaperone trigger factor accelerates the
                      folding of proteins as they emerge from the ribosome and
                      reveal the mechanism: By enhancing the polypeptide collapse,
                      it pushes residues together. Our mechanism promotes folding
                      to occur cotranslationally, impacts the many processes that
                      depend on it, like cotranslational protein assembly,
                      translation arrest mitigation, and aggregation suppression,
                      and can help explain how trigger factor interacts with
                      downstream chaperones and how cells produce proteins with
                      limited errors.},
      cin          = {ER-C-3},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40711920},
      UT           = {WOS:001544079300001},
      doi          = {10.1073/pnas.2422678122},
      url          = {https://juser.fz-juelich.de/record/1044990},
}