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001045525 1001_ $$0P:(DE-HGF)0$$aJiang, Lin$$b0
001045525 245__ $$aGene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability
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001045525 520__ $$aThe relationship between brain structure and function, known as structural-functional coupling (SFC), is highly dynamic. However, the temporal variability of this relationship, referring to the fluctuating extent to which functional profiles interact with anatomy over time, remains poorly elucidated. Here, we propose a framework to quantify SFC temporal variability and determine its neurocognitive map, genetic architecture, and neurochemical basis in 1206 healthy human participants. Results reveal regional heterogeneity in SFC variability and a composite emotion dimension co-varying with variability patterns involving the dorsal attention, somatomotor, and visual networks. The transcriptomic signatures of SFC variability are enriched in synapse- and cell cycle-related biological processes and implicated in emotion-related disorders. Moreover, regional densities of serotonin, glutamate, γ-aminobutyric acid, and opioid systems are predictive of SFC variability across the cortex. Collectively, SFC variability mapping provides a biologically plausible framework for understanding how SFC fluctuates over time to support macroscale neurocognitive specialization.
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001045525 7001_ $$0P:(DE-Juel1)161225$$aGenon, Sarah$$b1
001045525 7001_ $$0P:(DE-HGF)0$$aYe, Jiayu$$b2
001045525 7001_ $$0P:(DE-HGF)0$$aZhu, Yan$$b3
001045525 7001_ $$0P:(DE-HGF)0$$aWang, Guangying$$b4
001045525 7001_ $$0P:(DE-HGF)0$$aHe, Runyang$$b5
001045525 7001_ $$0P:(DE-HGF)0$$aValdes-Sosa, Pedro A.$$b6
001045525 7001_ $$0P:(DE-HGF)0$$aWan, Feng$$b7
001045525 7001_ $$0P:(DE-HGF)0$$aYao, Dezhong$$b8
001045525 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b9
001045525 7001_ $$0P:(DE-Juel1)190904$$aDong, Debo$$b10$$eCorresponding author$$ufzj
001045525 7001_ $$0P:(DE-HGF)0$$aLi, Fali$$b11
001045525 7001_ $$0P:(DE-HGF)0$$aXu, Peng$$b12$$eCorresponding author
001045525 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-63000-5$$gVol. 16, no. 1, p. 7623$$n1$$p7623$$tNature Communications$$v16$$x2041-1723$$y2025
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001045525 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)190904$$a Faculty of Psychology, Southwest University, Chongqing, 400715, China$$b10
001045525 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a     The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China     Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 611731, China     Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, 2019RU035, Chengdu, China$$b12
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