TY  - JOUR
AU  - Jiang, Lin
AU  - Genon, Sarah
AU  - Ye, Jiayu
AU  - Zhu, Yan
AU  - Wang, Guangying
AU  - He, Runyang
AU  - Valdes-Sosa, Pedro A.
AU  - Wan, Feng
AU  - Yao, Dezhong
AU  - Eickhoff, Simon B.
AU  - Dong, Debo
AU  - Li, Fali
AU  - Xu, Peng
TI  - Gene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - FZJ-2025-03530
SP  - 7623
PY  - 2025
AB  - The relationship between brain structure and function, known as structural-functional coupling (SFC), is highly dynamic. However, the temporal variability of this relationship, referring to the fluctuating extent to which functional profiles interact with anatomy over time, remains poorly elucidated. Here, we propose a framework to quantify SFC temporal variability and determine its neurocognitive map, genetic architecture, and neurochemical basis in 1206 healthy human participants. Results reveal regional heterogeneity in SFC variability and a composite emotion dimension co-varying with variability patterns involving the dorsal attention, somatomotor, and visual networks. The transcriptomic signatures of SFC variability are enriched in synapse- and cell cycle-related biological processes and implicated in emotion-related disorders. Moreover, regional densities of serotonin, glutamate, γ-aminobutyric acid, and opioid systems are predictive of SFC variability across the cortex. Collectively, SFC variability mapping provides a biologically plausible framework for understanding how SFC fluctuates over time to support macroscale neurocognitive specialization.
LB  - PUB:(DE-HGF)16
C6  - 40817330
UR  - <Go to ISI:>//WOS:001551663400044
DO  - DOI:10.1038/s41467-025-63000-5
UR  - https://juser.fz-juelich.de/record/1045525
ER  -